Use of phosphotriester intermediates for preparation of functionalized liposomes
Patent 4480041 Issued on October 30, 1984. Estimated Expiration Date: 
July 9, 2002. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
July 9, 2002. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3850578 Process of determining an immunogenic substance by competition with an antibody in a microcapsule Immunoassay products and methods Chemical luminescence amplification substrate system for immunochemistry involving microencapsulated fluorescer Patent #: 4372745 InventorsAssigneeApplicationNo. 06/396678 filed on 07/09/1982US Classes:436/508, Antinuclear (e.g., DNA, etc.)435/7.9, Assay in which an enzyme present is a label436/500, THYROID HORMONE TESTS (E.G., T3, T4, TBG, TSH, ETC.)436/528, Carrier is organic436/536, INVOLVING IMMUNE COMPLEX FORMED IN LIQUID PHASE436/816, Alkaloids, amphetamines, and barbiturates436/817, Steroids or hormones436/829LIPOSOMES (E.G., ENCAPSULATION, ETC.)ExaminersPrimary: Marantz, SidneyAttorney, Agent or FirmInternational ClassG01N 33/58 (20060101)AbstractA method of forming an analyte-functionalized liposome for use in immunoassay techniques employs a phosphotriester intermediate of a phospholipid derivatized with the desired analyte in a process of forming a liposome which is functionalized on its outer surface with the analyte and which carries an enzyme marker. The method is also used to functionalize the liposome with a ligand which acts as a leash between the analyte and the liposome. Liposomes produced by the method include penicillin-G-functionalized liposome. |
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