Process for preparation of microspheres and modification of release rate of core material
Patent 4479911 Issued on October 30, 1984. Estimated Expiration Date: 
March 8, 2003. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
March 8, 2003. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3872023 3886084 Preparation of microcapsules Process for encapsulation of medicaments Processes for preparation of microspheres Process for preparation of microspheres Patent #: 4384975 InventorAssigneeApplicationNo. 06/472886 filed on 03/08/1983US Classes:264/4.6, Solid-walled microcapsule formed by physically removing a constituent (e.g., evaporation, extraction, etc.)264/4.3, With treatment subsequent to solid wall formation (e.g., coating, hardening, etc.)264/4.7, Solid-walled microcapsule formed by in situ polymerization424/497, Containing solid synthetic polymers427/2.21, Retarded or controlled-release layer produced (e.g., enteric)427/213.36, Solid-walled microcapsule formed from preformed synthetic polymer428/402.24Microcapsule with solid core (includes liposome)ExaminersPrimary: Lovering, Richard D.Assistant: Brookes, Anne Attorney, Agent or FirmInternational ClassesA61K 9/16 (20060101)B01J 13/06 (20060101) B01J 13/12 (20060101) AbstractThis invention provides for the production of microspheres in an oil-in-water emulsion process using an emulsifier, whereby solvent removal from the oil phase allows for isolation of discrete microspheres, wherein the release rate of a core material is modified by the use of an alkaline agent, e.g. sodium hydroxide, during the preparation of the microspheres. | |
