Ocular preparation housing steroid in two different therapeutic forms

Patent 4478818 Issued on October 23, 1984. Estimated Expiration Date:

January 5, 2004. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

2932606

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Inventors

Application

No. 06/568480 filed on 01/05/1984

US Classes:

424/426, Errodable, resorbable, or dissolving424/427, Ocular424/78.04, Ophthalmic preparation514/171, With additional active ingredient514/912OPHTHALMIC

Examiners

Primary: Rose, Shep K.

Attorney, Agent or Firm

International Class

A61K 9/00 (20060101)

Abstract

An ocular insert and an ocular composition are disclosed. The insert and the composition comprises a steroid in two different forms.

Other References

Higuchi et al., J. Pharm. Sci., vol. 52, No. 1, pp. 67-71, 1963, Dissolution Rates of Finely Divided Powders, 1, Effect of a Distribution of Particle Sizes in a Diffusion-Controlled Process
Higuchi et al., J. Pharm. Sci., vol. 52, No. 2, pp. 150-159, 1963, Polymorphism and Drug Availability, Solubility Relationships in Methylprednisolone System
Higuchi et al., J. Pharm. Sci., vol. 52, No. 2, pp. 162-164, 1963, Dissolution Rates of Finely Divided Drug Powders II, Micronized Methylprednisolone
Haleblian et al., J. Pharm. Sci., vol. 58, No. 8, pp. 911-929, 1969, Pharmaceutical Applications of Polymorphism
Haleblian et al., J. Pharm. Sci., vol. 60, No. 10, pp. 1485-1491, 1971, Isolation and Characterization of Some Solid Phases of Fluprednisolone
Haleblian, J. Pharm. Sci., vol. 64, No. 8, pp. 1269-1288, 1975, Characterization of Habits and Crystalline Modifications of Solids and Their Pharmaceutical Applications