Patent References 2040806 3557795 Oligodynamic catheter Coated metallic bone joint prosthesis resistant to synovial fluid corrosion Patent #: 4263681 InventorsAssigneeApplicationNo. 06/328594 filed on 11/23/1981US Classes:623/23.57, Including bioactive coating606/76, Specialized coating or material977/722On a metal substrateExaminersPrimary: Padgett, Benjamin R.Assistant: Wallen, T. J. Attorney, Agent or FirmInternational ClassesA61B 17/86 (20060101)A61B 17/80 (20060101) A61F 2/30 (20060101) A61B 17/68 (20060101) A61L 27/54 (20060101) A61L 27/00 (20060101) A61N 1/20 (20060101) A61F 2/00 (20060101) A61F 2/02 (20060101) A61B 17/06 (20060101) Foreign Application Priority Data1980-03-27 GBAbstractSurgical implants, especially endoprosthetic orthopaedic implants and sutures, are rendered antimicrobial by the presence of a bioerodible metallic silver component, especially a surface coating, which provides in vivo a sustained release of silver ions in a concentration sufficient to provide a localized antimicrobial effect but insufficient to cause significant damage to connective tissue. Latently bioerodible silver components of an implant can be activated by, for example, abrasion, heating to above about 180° C. or, especially, contact with hydrogen peroxide.Other References
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