U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Antimicrobial surgical implants

Patent 4476590 Issued on October 16, 1984. Estimated Expiration Date: Icon_subject November 23, 2001. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

2040806

3557795

Oligodynamic catheter
Patent #: 4054139
Issued on: 10/18/1977
Inventor: Crossley

Coated metallic bone joint prosthesis resistant to synovial fluid corrosion Patent #: 4263681
Issued on: 04/28/1981
Inventor: Notton

Inventors

Assignee

Application

No. 06/328594 filed on 11/23/1981

US Classes:

623/23.57, Including bioactive coating606/76, Specialized coating or material977/722On a metal substrate

Examiners

Primary: Padgett, Benjamin R.
Assistant: Wallen, T. J.

Attorney, Agent or Firm

International Classes

A61B 17/86 (20060101)
A61B 17/80 (20060101)
A61F 2/30 (20060101)
A61B 17/68 (20060101)
A61L 27/54 (20060101)
A61L 27/00 (20060101)
A61N 1/20 (20060101)
A61F 2/00 (20060101)
A61F 2/02 (20060101)
A61B 17/06 (20060101)

Foreign Application Priority Data

1980-03-27 GB

Abstract

Surgical implants, especially endoprosthetic orthopaedic implants and sutures, are rendered antimicrobial by the presence of a bioerodible metallic silver component, especially a surface coating, which provides in vivo a sustained release of silver ions in a concentration sufficient to provide a localized antimicrobial effect but insufficient to cause significant damage to connective tissue. Latently bioerodible silver components of an implant can be activated by, for example, abrasion, heating to above about 180° C. or, especially, contact with hydrogen peroxide.

Other References

  • "Prophylaxis of Indwelling Urethral Catheter . . . ", Akiyami et al., J. of Urology, 4-1978, vol. 121
  • "An In-Vivo Study of Bacterial Response to Inert and Reactive Metals . . . ", Gristina et al., J. of Biomed Mater. Res., Wiley, vol. 10, pp. 273-281 (1976)
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