U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Propranolol immunogen and antibodies

Patent 4472301 Issued on September 18, 1984. Estimated Expiration Date: Icon_subject May 27, 2002. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3654090

3817837

Antibody steric hindrance immunoassay with two antibodies
Patent #: 3935074
Issued on: 01/27/1976
Inventor: Rubenstein ,   et al.

Fluorescence quenching with immunological pairs in immunoassays
Patent #: 3996345
Issued on: 12/07/1976
Inventor: Ullman ,   et al.

Double receptor fluorescent immunoassay
Patent #: 3998943
Issued on: 12/21/1976
Inventor: Ullman

Antigen-containing propranolol derivatives
Patent #: 4026879
Issued on: 05/31/1977
Inventor: Spector

Propranolol assay
Patent #: 4070492
Issued on: 01/24/1978
Inventor: Spector

Test article including a covalently attached diagnostic reagent and method
Patent #: 4133639
Issued on: 01/09/1979
Inventor: Harte

Specific binding assay with an enzyme modulator as a labeling substance
Patent #: 4134792
Issued on: 01/16/1979
Inventor: Boguslaski ,   et al.

Receptor fluorescent immunoassay
Patent #: 4160016
Issued on: 07/03/1979
Inventor: Ullman

More ...

Inventors

Assignee

Application

No. 06/383340 filed on 05/27/1982

US Classes:

530/363, Serum albumin, e.g., BSA, HSA, etc.435/7.7, Assay in which a label present is an apoenzyme, prosthetic group, or enzyme cofactor435/7.71, Assay in which a label present is an enzyme inhibitor or functions to alter enzyme activity435/7.72, Assay in which a label present is an enzyme substrate or substrate analogue435/7.9, Assay in which an enzyme present is a label530/345, Chemical aftertreatment, e.g., acylation, methylation, etc.530/389.8, Binds drug, hapten, hapten-carrier complex, or specifically-identified chemical structure (e.g., theophylline, digoxin, etc.)530/404, Sulfur containing reactant530/405, Nitrogen containing reactant530/806, ANTIGENIC PEPTIDES OR PROTEINS530/809Fused cells, e.g., hybridoma, etc.

Examiners

Primary: Kight, John
Assistant: Draper, Garnette D.

Attorney, Agent or Firm

International Classes

G01N 33/94 (20060101)
C07H 21/00 (20060101)
C07D 295/00 (20060101)
C07D 295/13 (20060101)
C07H 17/075 (20060101)
C07H 17/00 (20060101)
G01N 33/531 (20060101)
G01N 33/542 (20060101)
G01N 33/536 (20060101)

Abstract

A propranolol immunogen comprising an unsubstituted hydroxypropylamine precursor of propranolol coupled through a bis-imidate linking group to an immunogenic carrier material. The immunogen is useful to stimulate the production of antibodies which recognize propranolol and can perform as reagents in immunoassays to determine propranolol.

Other References

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  • Br. Med. Bull., 30:24-31 (1974), J. H. L. Playfiar et al., "Production of Antibodies & Binding Reagents"
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  • Europ. J. Med. Chem., 12:465 (1977), R. T. Buckler et al., "The Synthesis and Biological Activity . . . F2଱ "
  • Nature, 266:495 (1977), K. L. Welsh, "Antibody Production Made Easier"
  • Science, 208:692 (1980), N. Wade, "Hybridomas: A Potent New Biotechnology"
  • Methods in Enzymol., 73:3 (1981), G. Galfre et al., "Preparation of Monoclonal Antibodies: . . . "
  • J. Exp. Med., 122:1029 (1965), W. B. Dandliker et al., "Study of Penicillin Antibodies . . . Immunodiffusion"
  • J. Chem. Soc., pp. 1571-1577 (1954), O. Stephenson, "The Condensation of Epichlorohydrin . . . with Catechol"
  • Clinica Chimica Acta, 57:263 (1974), C. Bohuon et al., "Radioimmunoassay of Methotrexate in Biological Fluids"
  • Anal. Biochem., 1:66 (1960), J. D. Mandell et al., "A Fractionating Column for . . . Acids"
  • Clin. Chem., 23(8):1402 (1977), J. F. Burd et al., "Homogeneous Reactant-Labeled . . . Human Serum"
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