U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Polymeric diffusion matrix

Patent 4470962 Issued on September 11, 1984. Estimated Expiration Date: Icon_subject September 11, 2001. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

1280149

2127896

2138751

2155658

2160503

2340866

2491642

2693438

2698822

2726982

More ...

Inventors

Assignee

Application

No. 06/258456 filed on 04/28/1981

US Classes:

424/449, Transdermal or percutaneous424/448, Pressure sensitive adhesive means424/486Synthetic polymer

Examiners

Primary: Rose, Shep K.

Attorney, Agent or Firm

International Class

A61K 9/70 (20060101)

Foreign Application Priority Data

1979-08-14 JP

Abstract

A polymeric diffusion matrix is provided comprising from about 2 to about 60% glycerol, from about 2 to about 15% polyvinylalcohol, from about 2 to about 10% water soluble polymer with hydration sites which in combination with the remaining ingredients yields a matrix capable of sustained release of a drug dispersed therein, and the balance water, the percentages being by weight.

Other References

  • Fung et al., J. Pharm. Sci., 63(11):1810-1811, Nov. 1974, Development of a Stable Sublinear Nitroglycerin Tablet I: Interaction of Nitroglycerin with Selected Macromolecules PVP
  • Vishnevski, A. A. et al., U.S.S.R. 219116, Mar. 20, 1973, from Otkrytiya, Izobret. Prom. Obraztsy, Tovarny Znaki, 1973, 50(15), 170
  • Chem. Abstracts, vol. 79, No. 8, Aug. 27, 1973, #45845b, p. 215, col. 2, U.S.S.R. 219116, Mar. 20, 1973, A. A. Vishnevski et al., Protective and Medicated Film for the Initial Treatment of Scalds
  • Ward et al., Amer. Perf. & Cosmetics, 79:53-55, Nov. 1964, The Use of Polyvinyl Alcohol in Film-Forming Bases
  • Ward et al., J. Soc. Cos. Chem., 15:327-335, (1964), Cosmetic Applications of Polyvinyl Alcohol
  • Toydshima, K., "Compatibility of Polyvinyl Alcohol with Other Water-Soluble High Polymers", in Finch et al., ED, (1967), Polyvinyl Alcohol: Properties & Applications, 535-553
  • Ban et al., Pharmazie, 29H9:597-602, (1974), (PVP-PVA)
  • Nagy et al., "Formation of Disperse Structures in Polymer Gels", Proc. Int. Conf. Colloid & Surface Science, Budapest, Hungary, Sep. 1975, Wolfram Ed., pp. 447-453
  • Peierls, Modern Plastics, 18:53-56, Feb. 1941, Polyvinyl Alcohol Plastics
  • Hess et al., Rubber Age, 53:431-433, Aug. 1973, Molding Polyvinyl Alcohol
  • Ita et al., Bulletin Pharm. Research Inst., Osaka Medical College, (2), 1-3, (1951), II, "On a New Water-Soluble Ointment"
  • Hirai, Bull. Inst. Chem., Koyoto Univ., 33:21-37, (1955), The Gel-Elasticity of High Polymers
  • Langhammer et al., Naturwissen Schaften, 43:125-126, (1956), (PVP-PVA)
  • (PVP-PVA), Nehring Plaste und Kautschuk, 3:279-280, (1956)
  • Windholz et al., The Merck Index, 9th Ed., (1976), Merck & Co., Rahway, NJ, p. 471, Entry 3534, Ephedrine, ଱[1-(Methylamino)Ethyl]Benzene-Methanol, (Bronchodilator)
  • Riegelman, Clinical Pharmacology & Therapeutics, 16, (Apr. 5, 1912), 873-883, (1974), Pharmacokinetic Factors Affecting Epidermal Penetration and Percutaneous Absorption
  • Graybiel et al., Aviation Space & Environmental Medicine, 52:337-339, (1981), "Efficacy of Transdermal . . . Ephedrine"
  • Graybiel et al., Aviation Space & Environmental Medicine, 47(10):1096-1100, (1976)
  • Shaw et al., 14 Controlled Transdermal Delivery in vitro and in vivo, pp. 138-146, Animal Models in Dermatology
  • Beckett et al., Pharm. Pharmac., 1972, 24 Suppl., 65 P-70 P, Comparison of Oral and Percotanedes Routes in Man for the Systemic Administration of "Ephedrines"
  • Gross I: Gross et al., Archiv f/u/ r Tokikologie, vol. 18, 194-199, (1960)
  • Gross II: Gross et al., Archiv f/u/ r Tokikologie, vol. 18, 331-334, (1960)
  • PDR: Physician's Desk Reference, Entry for "Nitrol(R) Ointment", 675, (1958)
  • Davis: Davis et al., Am. Jour. Medical Sciences, 259-263, (Sep. 1955)
  • Lund: Acta Med. Scand., Suppl. 206; 196-206, (Jun. 1948)
  • Roseman: Roseman et al., Jour. Pharm. Sci., vol. 59, pp. 353-357, (Mar. 1970)
  • Kincl: Kincl et al., Steroids, vol. 11, pp. 673-680, (May 1968)
PatentsPlus Images
Enhanced PDF formats
loading...
PatentsPlus: add to cart
PatentsPlus: add to cartSearch-enhanced full patent PDF image
$9.95more info
PatentsPlus: add to cart
PatentsPlus: add to cartIntelligent turbocharged patent PDFs with marked up images
$18.95more info
 
Sign InRegister
Username  
Password   
forgot password?