Patent 4470962 Issued on September 11, 1984. Estimated Expiration Date: September 11, 2001. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
A polymeric diffusion matrix is provided comprising from about 2 to about 60% glycerol, from about 2 to about 15% polyvinylalcohol, from about 2 to about 10% water soluble polymer with hydration sites which in combination with the remaining ingredients yields a matrix capable of sustained release of a drug dispersed therein, and the balance water, the percentages being by weight.
Other References
Fung et al., J. Pharm. Sci., 63(11):1810-1811, Nov. 1974, Development of a Stable Sublinear Nitroglycerin Tablet I: Interaction of Nitroglycerin with Selected Macromolecules PVP
Vishnevski, A. A. et al., U.S.S.R. 219116, Mar. 20, 1973, from Otkrytiya, Izobret. Prom. Obraztsy, Tovarny Znaki, 1973, 50(15), 170
Chem. Abstracts, vol. 79, No. 8, Aug. 27, 1973, #45845b, p. 215, col. 2, U.S.S.R. 219116, Mar. 20, 1973, A. A. Vishnevski et al., Protective and Medicated Film for the Initial Treatment of Scalds
Ward et al., Amer. Perf. & Cosmetics, 79:53-55, Nov. 1964, The Use of Polyvinyl Alcohol in Film-Forming Bases
Ward et al., J. Soc. Cos. Chem., 15:327-335, (1964), Cosmetic Applications of Polyvinyl Alcohol
Toydshima, K., "Compatibility of Polyvinyl Alcohol with Other Water-Soluble High Polymers", in Finch et al., ED, (1967), Polyvinyl Alcohol: Properties & Applications, 535-553
Ban et al., Pharmazie, 29H9:597-602, (1974), (PVP-PVA)
Nagy et al., "Formation of Disperse Structures in Polymer Gels", Proc. Int. Conf. Colloid & Surface Science, Budapest, Hungary, Sep. 1975, Wolfram Ed., pp. 447-453
Peierls, Modern Plastics, 18:53-56, Feb. 1941, Polyvinyl Alcohol Plastics
Hess et al., Rubber Age, 53:431-433, Aug. 1973, Molding Polyvinyl Alcohol
Ita et al., Bulletin Pharm. Research Inst., Osaka Medical College, (2), 1-3, (1951), II, "On a New Water-Soluble Ointment"
Hirai, Bull. Inst. Chem., Koyoto Univ., 33:21-37, (1955), The Gel-Elasticity of High Polymers
Langhammer et al., Naturwissen Schaften, 43:125-126, (1956), (PVP-PVA)
(PVP-PVA), Nehring Plaste und Kautschuk, 3:279-280, (1956)
Windholz et al., The Merck Index, 9th Ed., (1976), Merck & Co., Rahway, NJ, p. 471, Entry 3534, Ephedrine, [1-(Methylamino)Ethyl]Benzene-Methanol, (Bronchodilator)
Graybiel et al., Aviation Space & Environmental Medicine, 52:337-339, (1981), "Efficacy of Transdermal . . . Ephedrine"
Graybiel et al., Aviation Space & Environmental Medicine, 47(10):1096-1100, (1976)
Shaw et al., 14 Controlled Transdermal Delivery in vitro and in vivo, pp. 138-146, Animal Models in Dermatology
Beckett et al., Pharm. Pharmac., 1972, 24 Suppl., 65 P-70 P, Comparison of Oral and Percotanedes Routes in Man for the Systemic Administration of "Ephedrines"
Gross I: Gross et al., Archiv f/u/ r Tokikologie, vol. 18, 194-199, (1960)
Gross II: Gross et al., Archiv f/u/ r Tokikologie, vol. 18, 331-334, (1960)
PDR: Physician's Desk Reference, Entry for "Nitrol(R) Ointment", 675, (1958)
Davis: Davis et al., Am. Jour. Medical Sciences, 259-263, (Sep. 1955)