Patent References 3725545 Nuclease-resistant hydrophilic complex of polyriboinosinic-polyribocytidylic acid Antigens comprising immunostimulant adjuvants and their use in immunotherapy Patent #: 4285930 InventorsAssigneeApplicationNo. 06/236534 filed on 02/20/1981US Classes:424/197.11, Conjugate or complex includes bacterium or component thereof or substance produced by said bacterium424/234.1, Bacterium or component thereof or substance produced by said bacterium (e.g., Legionella, Borrelia, Anaplasma, Shigella, etc.)424/243.1, Staphylococcus (e.g., Staphylococcus aureus, etc.)424/244.1, Streptococcus (e.g., Group B Streptococcus, pneumococcus or Streptococcus pneumoniae, etc.)424/245.1, Corynebacterium (e.g., Corynebacterium diphtheriae, etc.)424/248.1, Mycobacterium (e.g., Mycobacterium tuberculosis, Calmette-Guerin bacillus (i.e., BCG), etc.)424/250.1, Neisseria meningitidis424/256.1, Hemophilus (e.g., Hemophilus influenzae, Hemophilus gallinarum, Hemophilus pleuropnemoniae, etc.)424/257.1, Escherichia (e.g., Escherichia coli, etc.)424/258.1, Salmonella (e.g., Salmonella typhimurium, etc.)424/259.1, Klebsiella (e.g., Klebsiella pneumoniae, etc.)424/831, INVOLVING CAPSULAR POLYSACCHARIDE OF BACTERIUM (E.G., POLYRIBOSYL RIBITOL PHOSPHATE (PRP), ETC.)530/405, Nitrogen containing reactant530/807, HAPTEN CONJUGATED WITH PEPTIDE OR PROTEIN536/23.1, DNA or RNA fragments or modified forms thereof (e.g., genes, etc.)536/24.2Non-coding sequences having no known regulatory function which are adaptors or linkers for vector or gene contructionExaminersPrimary: Hazel, BlondelAttorney, Agent or FirmInternational ClassA61K 39/39 (20060101)Foreign Application Priority Data1980-02-20 FRAbstractThe present invention relates to a vaccinal complex containing a specific antigen. This is a vaccinal complex characterized in that it is composed of bacterial ribosomal RNA or fragments of bacterial ribosomal RNA on which are coupled from 1 to 5% by weight of a specific antigen of bacterial serotype. This complex may be used as a vaccine.Other References
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