Cholesterol matrix delivery system for sustained release of macromolecules

Patent 4452775 Issued on June 5, 1984. Estimated Expiration Date:

December 3, 2002. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

3800038

3828106

Systems for the controlled release of macromolecules
Patent #: 4164560
Issued on: 08/14/1979
Inventor: Folkman , et al.

Inert core implant pellet
Patent #: 4180560
Issued on: 12/25/1979
Inventor: Katz , et al.

Manufacture of long term contraceptive implant Patent #: 4244949
Issued on: 01/13/1981
Inventor: Gupta

Inventor

Kent, John S.

Application

No. 06/446749 filed on 12/03/1982

US Classes:

424/425, Diffusion barrier is matrix424/430, Vaginal, urethral, uterine424/484, Matrices514/12, 25 or more peptide repeating units in known peptide chain structure514/3, Insulin or derivative514/772, DESIGNATED ORGANIC NONACTIVE INGREDIENT CONTAINING OTHER THAN HYDROCARBON930/120Growth hormone, growth factor other than T-cell or B-cell growth factor, and growth hormone releasing factor; related peptides

Examiners

Primary: Rose, Shep K.

Attorney, Agent or Firm

International Class

A61K 9/20 (20060101)

Abstract

Delivery systems for releasing macromolecular active agents to a body site at a controlled rate for a prolonged period of time, comprising a cholesteric matrix permeable to passage of the macromolecular active agent by diffusion, are disclosed. The cholesteric matrix comprises cholesterol powder and cholesterol prills optionally in combination with a binding agent and a lubricating agent. The macromolecular active agent is dispersed throughout the matrix; macromolecules suitable for release from this delivery system have molecular weights of about 1300 to about 75,000 and are at least very slightly soluble in water.