Anti-D test and reagent
Antigenic modification of polypeptides
Antitumor hybrid and process for the preparation thereof
Process for the selective formation of disulfide bridges in polypeptides and therapeutic compositions Patent #: 4351764
ApplicationNo. 06/333214 filed on 12/21/1981
US Classes:530/391.9, Conjugated via a specifically-identified linking group, coupling agent, or conjugation agent530/377, Derived from oil seed, e.g., cotton seed, rapeseed, sunflower, etc.530/389.6, Binds hematopoietic cell or component or product thereof (e.g., erythrocyte, granulocyte, bone marrow cell, lymphocyte, leukemic cell, hematopoietic cell-surface antigen, hemoglobin, etc.)530/395, Glycoprotein, e.g., mucins proteoglycans, etc.530/408, Sulfur containing reactant530/866INVOLVING IMMUNOGLOBULIN OR ANTIBODY FRAGMENT, (E.G., F(AB)'2, FAB', FAB, FV, FC, HEAVY CHAIN, LIGHT CHAIN, ETC.)
ExaminersPrimary: Phillips, Delbert R.
Attorney, Agent or Firm
International ClassA61K 47/48 (20060101)
Foreign Application Priority Data1979-07-20 JP
AbstractAntitumor protein hybrid, composed of a moiety which is substantially the fragment Fab of an antitumor immunogloblin and a moiety which is the subunit A of ricin, which is expressed by the following formula (I):(where Fab indicates a moiety which is substantially the fragment Fab of an antitumor immunogloblin; RA indicates a moiety which is the subunit A of ricin; X indicates a divalent organic radical; S1 and S2 are both sulfur atoms, S1 indicating a sulfur atom arising from the disulfide bond (--S--S-- bond) in an immunoglobulin and S2 a sulfur atom arising from the disulfide bond in ricin; n stands for 0 or 1 and m stands for an integer of 1 to 5). This antitumor protein hybrid has remarkable and specific cytotoxicity against tumor cells.