Antitumor hybrid and process for the preparation thereof
Patent 4450154 Issued on May 22, 1984. Estimated Expiration Date: 
December 21, 2001. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
December 21, 2001. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesAnti-D test and reagent Antigenic modification of polypeptides Antitumor hybrid and process for the preparation thereof Process for the selective formation of disulfide bridges in polypeptides and therapeutic compositions Patent #: 4351764 InventorsAssigneeApplicationNo. 06/333214 filed on 12/21/1981US Classes:530/391.9, Conjugated via a specifically-identified linking group, coupling agent, or conjugation agent530/377, Derived from oil seed, e.g., cotton seed, rapeseed, sunflower, etc.530/389.6, Binds hematopoietic cell or component or product thereof (e.g., erythrocyte, granulocyte, bone marrow cell, lymphocyte, leukemic cell, hematopoietic cell-surface antigen, hemoglobin, etc.)530/395, Glycoprotein, e.g., mucins proteoglycans, etc.530/408, Sulfur containing reactant530/866INVOLVING IMMUNOGLOBULIN OR ANTIBODY FRAGMENT, (E.G., F(AB)'2, FAB', FAB, FV, FC, HEAVY CHAIN, LIGHT CHAIN, ETC.)ExaminersPrimary: Phillips, Delbert R.Attorney, Agent or FirmInternational ClassA61K 47/48 (20060101)Foreign Application Priority Data1979-07-20 JPAbstractAntitumor protein hybrid, composed of a moiety which is substantially the fragment Fab of an antitumor immunogloblin and a moiety which is the subunit A of ricin, which is expressed by the following formula (I):(where Fab indicates a moiety which is substantially the fragment Fab of an antitumor immunogloblin; RA indicates a moiety which is the subunit A of ricin; X indicates a divalent organic radical; S1 and S2 are both sulfur atoms, S1 indicating a sulfur atom arising from the disulfide bond (--S--S-- bond) in an immunoglobulin and S2 a sulfur atom arising from the disulfide bond in ricin; n stands for 0 or 1 and m stands for an integer of 1 to 5). This antitumor protein hybrid has remarkable and specific cytotoxicity against tumor cells. |
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