Method of using certain substituted aliphatic secondary amines or their salts for easing breathing
Patent 4448776 Issued on May 15, 1984. Estimated Expiration Date: 
January 20, 2002. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
January 20, 2002. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 2483434 2627491 3013020 3401224 3483209 3501527 3551492 3876702 Anti-arrhythmic agents 4091220 InventorsApplicationNo. 06/341035 filed on 01/20/1982US Classes:514/252.12, Piperazines (i.e., fully hydrogenated 1,4-diazines)514/255.04, Plural carbocyclic rings bonded directly to the same acyclic carbon atom which is attached directly or indirectly to the piperazine ring by nonionic bonding514/546, ZC(=O)OY, wherein Z is an acyclic radical bonded to the C=O by a carbon and Y is an organic radical bonded to the oxygen by a carbon514/648, Two aryl rings or aryl ring systems bonded directly to the same acyclic carbon514/649Amino nitrogen attached to aryl ring or aryl ring system by an acyclic carbon or acyclic chainExaminersPrimary: Schenkman, LeonardAttorney, Agent or FirmInternational ClassesC07C 229/00 (20060101)C07C 229/38 (20060101) Foreign Application Priority Data1981-02-12 CHAbstractCompounds of the formula Iin which R1 is unsubstituted or substituted phenyl, R2 is hydrogen lower alkyl, unsubstituted or substituted phenyl or free or esterified carboxy, and in which R3 is hydrogen or lower alkyl and R4 is a group of the formula --alk1 --X--alk2 --R5, or R3 and R4 together are a group of the formula --alk3 --NH--alk4 --, alk1 and alk2 being lower alkylidene, alk3 and alk4 lower alkylene, X a direct bond, methylene or unsubstituted or substituted phenylene and R5 being hydroxy, amino or substituted amino of the formula --N(R6)--CH(R7)--R8 in which R6 is hydrogen, or, provided that R3 is hydrogen, it may alternatively be lower alkyl or unsubstituted or substituted phenyl-lower alkyl, R7 is hydrogen, lower alkyl, unsubstituted or substituted phenyl or free or esterified carboxy and R8 is unsubstituted or substituted phenyl, and their pharmaceutically acceptable salts have properties that ease breathing and are suitable for combating respiratory disorders, preferably as active ingredients in and/or for the manufacture of pharmaceutical preparations that ease breathing.Other References
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