U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Method and composition for treating atherosclerosis

Patent 4444778 Issued on April 24, 1984. Estimated Expiration Date: Icon_subject August 13, 2002. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3846476

3852338

Process and composition for decreasing blood serum prolactin levels Patent #: 4224343
Issued on: 09/23/1980
Inventor: Wurtman

Inventor

Application

No. 06/407960 filed on 08/13/1982

US Classes:

514/280, Pentacyclo ring system having the six-membered hetero ring as one of the cyclos514/215, Additional hetero atom in the polycyclo ring system514/288, Ring carbon is shared by three of the cyclos514/324, Ring sulfur in the polycyclo ring system514/325, Polycyclo ring system is tricyclo-carbocyclic514/326, The additional ring is a hetero ring514/419, C=X bonded directly or indirectly by an acyclic carbon or carbon chain to ring carbon of the five-membered hetero ring (e.g., tryptophan, etc.) (X is chalcogen)514/654The chain consists of two or more carbons which are unsubtituted or have acyclic hydrocarbyl substituents only

Examiners

Primary: Schwartz, Richard A.

Attorney, Agent or Firm

International Classes

A61K 45/06 (20060101)
A61K 45/00 (20060101)
A61K 31/475 (20060101)
A61K 31/495 (20060101)

Abstract

A method of improving the arteriosclerotic condition in an animal having arteriosclerosis or having a high risk of developing arteriosclerosis, which method comprises administering an effective amount of a serotonin regulating agent, to inhibit the biological activity of serotonin within the blood vessels, thereby inhibiting the proliferation of smooth muscle cells, which has been found to cause or contribute to an arteriosclerotic condition.

Other References

  • Yamori, Y., et al., J. Pharm. Pharmac., 1972, 24 (9), 690-695
  • Goodman and Gilman's The Pharmacological Basis of Therapeutics, 6th Ed., Macmillan, New York, 1980, pp. 202-203
  • Ross, R., et al., New England J. Med., 295, 369-377 and 420-425 (1976)
  • Friedman, R., et al., Prog. Hemostasis and Thromb., 4, 249-278 (1978)
  • Coughlin, S., et al., Nature, 288, 600-602 (1980)
  • Goldberg, I., et al., Science, 205, 920-922 (1979)
  • Shimamoto, T., Acta Path. Jap. 19 (1), 15-43 (1969)
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