Antibiotic bonding of vascular prostheses and other implants
Patent 4442133 Issued on April 10, 1984. Estimated Expiration Date: 
February 22, 2002. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
February 22, 2002. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3425418 3520949 Non-thrombogenic articles Nonthrombogenic articles and method of preparation Patent #: 4302368 InventorsApplicationNo. 06/351324 filed on 02/22/1982US Classes:427/2.25, Liquid conveying (e.g., vascular, arterial, bile duct, urethra)427/2.28, Device for creating or holding open an unnatural opening in a membrane or organ (e.g., syringe, scalpel, drainage tube)623/921Blood vesselExaminersPrimary: Frinks, Ronald L.Attorney, Agent or FirmInternational ClassesA61L 27/00 (20060101)A61L 27/54 (20060101) A61L 27/50 (20060101) AbstractA method of preparing a surgical vascular graft wherein a length of graft material carries an absorbed coating of tridodecyl methyl ammonium chloride (TDMAC) surfactant and an antibiotic bound thereto. A length of graft material such as polytetrafluoroethylene or Dacron is soaked in a 5% by weight solution of TDMAC for 30 minutes at room temperature, air dried and then washed in distilled water to remove excess TDMAC. The graft carrying the absorbed cationic TDMAC surfactant coating is incubated in a solution of negatively charged antibiotic for one hour, washed in sterile water to remove unbound antibiotic and stored for use in the operating room. | |
