U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Long-term weight reduction of obese patients using femoxetine

Patent 4442113 Issued on April 10, 1984. Estimated Expiration Date: Icon_subject May 7, 2001. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3912743

Inventors

Assignee

Application

No. 06/261479 filed on 05/07/1981

US Classes:

514/317, Additional ring containing514/910Anorectic

Examiners

Primary: Robinson, Douglas W.

Attorney, Agent or Firm

International Classes

C07D 211/22 (20060101)
C07D 211/00 (20060101)
A61K 31/445 (20060101)

Abstract

A method for assisting with appetite and weight control and reduction in obese human patients, which comprises the step of orally or rectally administering an appetite-suppressant compound selected from the group consisting of femoxetine and a pharmaceutically-acceptable salt thereof in an effective appetite-suppressant amount over a period of at least eight (8) weeks is disclosed. The appetite-suppresssant compound is preferably orally administered together with a pharmaceutically-acceptable carrier in a daily dosage of 100 to 1,000 mg in the form of a tablet containing about 100 to 300 mg of the appetite-suppressant compound, which is preferably a pharmaceutically-acceptable femoxetine acid addition salt, especially the hydrochloride.

Other References

  • International J. of Obesity 1, pp. 15-42 (1977)--J. E. Blundell
  • Central Mechanisms of Ansr.-Drugs, pp. 83-109 (1978)--Garattin et al. or Blundell et al
  • Life Sciences 28, 77-82, (1981)--Hoebel et al
  • Drugs 10(4), 241--328 (1975)-Pinder et al
  • Alimentayinne Metabolism Nutrizione 1, 383 (1980), Wollesen et al
  • European J. of Pharm. 32, 108-115 (1975)--Lassen et al
  • Psychopharmacologia 42, 21-26 (1975)--Lassen et al
  • J. Chromatogr. 133, 147-152 (1977)--Bechgaard et al
  • Analytica Chimica Acta, 99, 189-192 (1978)--Bechgaard et al
  • J. Neurochemistry 24,47-50 (1975)--Squires
  • Lancet 1, 503-505 (1973)--Stunkard et al
  • Brit. J. of Psg. 123, 501-507 (1973)--Paykel et al
  • J. Pharm. Pharmac. 28, 318-320 (1976)--Goudie et al
  • Arzneim-Forsch (Drug Res.) 25 (11), 1758-1762 (1975)--Duhault et al
  • European J. of Pharmacol. 40, 121-130 (1976)--Sugrue et al
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