Patent References 3845770 Hydrophilic or hydrogel carrier systems such as coatings, body implants and other articles Ballistic inoculation of animals and projectile therefor Microporous drug delivery device Laminated osmotic system for dispensing beneficial agent Osmotic releasing device having a plurality of release rate patterns Osmotic system having laminated wall comprising semipermeable lamina and microporous lamina Osmotic device with compartment for governing concentration of agent dispensed from device System for delivering agent at zero order rate with emerging agent below saturation System with microporous releasing diffusor Patent #: 4309996 InventorAssigneeApplicationNo. 06/359447 filed on 03/18/1982US Classes:424/473, With porous, perforated, apertured, or sieved layer (e.g., dialyzing layer, microporous layer, etc.)604/892.1Osmotic or diffusion pumped device or systemExaminersPrimary: Padgett, Benjamin R.Assistant: Wallen, T. J. Attorney, Agent or FirmInternational ClassA61K 9/00 (20060101)AbstractAn osmotic drug (or other beneficial substance) delivery system comprises a multi-chamber compartment formed by an external shell and one or more chamber-dividing walls each with a small orifice, of a microporous material and overlayers of semipermeable membranes completely covering the outer shell of all but one chamber and substantially covering the outer shell of the remaining chamber. Osmotic agents, adjuvants, enzymes, drugs, pro-drugs, pesticides and the like are incorporated in the chambers covered by the semipermeable membrane, and external fluids that diffuse into those chambers form solutions and by osmotic pressure are forced through the orifice to the drug chamber to form a solution thereof and then through the exposed microporous shell to the exterior of the device at a rate controlled by the permeability of the semipermeable overlay and the osmotic pressure gradient across the shell. | |