U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Osmotic drug delivery system

Patent 4439196 Issued on March 27, 1984. Estimated Expiration Date: Icon_subject March 18, 2002. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3845770

Hydrophilic or hydrogel carrier systems such as coatings, body implants and other articles
Patent #: 3975350
Issued on: 08/17/1976
Inventor: Hudgin ,   et al.

Ballistic inoculation of animals and projectile therefor
Patent #: 3982536
Issued on: 09/28/1976
Inventor: Krogseng ,   et al.

Microporous drug delivery device
Patent #: 3993072
Issued on: 11/23/1976
Inventor: Zaffaroni

Laminated osmotic system for dispensing beneficial agent
Patent #: 4014334
Issued on: 03/29/1977
Inventor: Theeuwes ,   et al.

Osmotic releasing device having a plurality of release rate patterns
Patent #: 4093708
Issued on: 06/06/1978
Inventor: Zaffaroni, et al.

Osmotic system having laminated wall comprising semipermeable lamina and microporous lamina
Patent #: 4160452
Issued on: 07/10/1979
Inventor: Theeuwes

Osmotic device with compartment for governing concentration of agent dispensed from device
Patent #: 4210139
Issued on: 07/01/1980
Inventor: Higuchi

System for delivering agent at zero order rate with emerging agent below saturation
Patent #: 4298003
Issued on: 11/03/1981
Inventor: Theeuwes ,   et al.

System with microporous releasing diffusor Patent #: 4309996
Issued on: 01/12/1982
Inventor: Theeuwes

Inventor

Assignee

Application

No. 06/359447 filed on 03/18/1982

US Classes:

424/473, With porous, perforated, apertured, or sieved layer (e.g., dialyzing layer, microporous layer, etc.)604/892.1Osmotic or diffusion pumped device or system

Examiners

Primary: Padgett, Benjamin R.
Assistant: Wallen, T. J.

Attorney, Agent or Firm

International Class

A61K 9/00 (20060101)

Abstract

An osmotic drug (or other beneficial substance) delivery system comprises a multi-chamber compartment formed by an external shell and one or more chamber-dividing walls each with a small orifice, of a microporous material and overlayers of semipermeable membranes completely covering the outer shell of all but one chamber and substantially covering the outer shell of the remaining chamber. Osmotic agents, adjuvants, enzymes, drugs, pro-drugs, pesticides and the like are incorporated in the chambers covered by the semipermeable membrane, and external fluids that diffuse into those chambers form solutions and by osmotic pressure are forced through the orifice to the drug chamber to form a solution thereof and then through the exposed microporous shell to the exterior of the device at a rate controlled by the permeability of the semipermeable overlay and the osmotic pressure gradient across the shell.

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