U.S. patents available from 1976 to present.
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Polymeric diffusion matrix containing estrogens

Patent 4438139 Issued on March 20, 1984. Estimated Expiration Date: Icon_subject January 4, 2002. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

2127896

2138751

2155658

2160503

2340866

2491642

2693438

3287222

Flurandrenolide film formulation
Patent #: 4210633
Issued on: 07/01/1980
Inventor: Takruri ,   et al.

Polymeric diffusion matrix containing estradiol diacetate
Patent #: 4291014
Issued on: 09/22/1981
Inventor: Keith ,   et al.

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Inventors

Assignee

Application

No. 06/439023 filed on 01/04/1982

US Classes:

514/177, Oxygen double bonded to a ring carbon of the cyclopentanohydrophenanthrene ring system424/486, Synthetic polymer514/182Oxygen single bonded to a ring carbon of the cyclopentanohydrophenanthrene ring system

Examiners

Primary: Rose, Shep K.

Attorney, Agent or Firm

International Classes

A61K 9/00 (20060101)
A61K 31/135 (20060101)
A61K 9/70 (20060101)
A61K 31/415 (20060101)
A61K 31/565 (20060101)

Abstract

A polymeric diffusion matrix for the sustained release, intravaginal administration of an estrogen is provided. The matrix consists of polyvinylalcohol, polyvinylpyrrolidone and a polar plasticizer.

Other References

  • Peierls Modern Plastics 18: 53-56, Feb. 1941, Polyvinyl Alcohol Plastics
  • Hess et al., Rubber Age 53: 431-433, Aug. 1943, Molding Polyvinyl Alcohol
  • Ita et al., Bulletin Pharm. Research Inst., Osaka Medical College (2) 1-3, (1951) II, "On a New Water-Soluble Ointment"
  • Hirai Bull. Inst. Chem. Koyoto Univ. 33: 21-37, (1955), The Gel-Elasticity of High Polymers
  • Langhammer et al., Naturwissen Schaften 43: 125-126, (1956) (PVP-PVA)
  • (PVP-PVA) Nehring Plaste und Kautschuk 3: 279-280, (1956)
  • Ward et al., Amer. Perf. & Cosmetics 79: 52-55, Nov. 1964, The Use of Polyvinyl Alcohol in Film-Forming Bases
  • Ward et al., J. Soc. Cos. Chem. 15: 327-335, (1964), Cosmetic Applications of Polyvinyl Alcohol
  • Toydshima, K., "Compatibility of Polyvinyl Alcohol with Other Water-Soluble High Polymers", in Finch et al. Ed. (1967?), Polyvinyl Alcohol: Properties & Applications, 535-553
  • Ban et al., Pharmazie 29 H9: 597-602, (1974) (PVP-PVA)
  • Nagy et al., "Formation of Disperse Structures in Polymer Gels", Proc. Int. Conf. Colloid & Surface Science, Budapest Hungary, Sep. 1975, Wolfram et al., pp. 447-453
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