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US Patent 4438139 - Polymeric diffusion matrix containing estrogens

US Patent Issued on March 20, 1984
Estimated Patent Expiration Date: Icon_subject January 4, 2002Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
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Abstract

A polymeric diffusion matrix for the sustained release, intravaginal administration of an estrogen is provided. The matrix consists of polyvinylalcohol, polyvinylpyrrolidone and a polar plasticizer.

Other References

  • Peierls Modern Plastics 18: 53-56, Feb. 1941, Polyvinyl Alcohol Plastics
  • Hess et al., Rubber Age 53: 431-433, Aug. 1943, Molding Polyvinyl Alcohol
  • Ita et al., Bulletin Pharm. Research Inst., Osaka Medical College (2) 1-3, (1951) II, "On a New Water-Soluble Ointment"
  • Hirai Bull. Inst. Chem. Koyoto Univ. 33: 21-37, (1955), The Gel-Elasticity of High Polymers
  • Langhammer et al., Naturwissen Schaften 43: 125-126, (1956) (PVP-PVA)
  • (PVP-PVA) Nehring Plaste und Kautschuk 3: 279-280, (1956)
  • Ward et al., Amer. Perf. & Cosmetics 79: 52-55, Nov. 1964, The Use of Polyvinyl Alcohol in Film-Forming Bases
  • Ward et al., J. Soc. Cos. Chem. 15: 327-335, (1964), Cosmetic Applications of Polyvinyl Alcohol
  • Toydshima, K., "Compatibility of Polyvinyl Alcohol with Other Water-Soluble High Polymers", in Finch et al. Ed. (1967?), Polyvinyl Alcohol: Properties & Applications, 535-553
  • Ban et al., Pharmazie 29 H9: 597-602, (1974) (PVP-PVA)
  • Nagy et al., "Formation of Disperse Structures in Polymer Gels", Proc. Int. Conf. Colloid & Surface Science, Budapest Hungary, Sep. 1975, Wolfram et al., pp. 447-453

Inventors

Assignee

Application

No. 06/439023 filed on 01/04/1982

US Classes:

514/177, Oxygen double bonded to a ring carbon of the cyclopentanohydrophenanthrene ring system424/486, Synthetic polymer514/182Oxygen single bonded to a ring carbon of the cyclopentanohydrophenanthrene ring system

Examiners

Primary: Rose, Shep K.

Attorney, Agent or Firm

US Patent References

2127896, 2138751, 2155658, 2160503, 2340866, 2491642, 2693438, 3287222, 4210633, Flurandrenolide film formulation
Issued on: 07/01/1980
Inventor: Takruri ,   et al.
4291014, Polymeric diffusion matrix containing estradiol diacetate
Issued on: 09/22/1981
Inventor: Keith ,   et al.
4321252Polymeric diffusion matrix containing ester derivatives of estradiol
Issued on: 03/23/1982
Inventor: Keith ,   et al.

International Classes

A61K 9/00 (20060101)
A61K 31/135 (20060101)
A61K 9/70 (20060101)
A61K 31/415 (20060101)
A61K 31/565 (20060101)

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