Sterilized preserved, stable mucine-containing solutions

Patent 4438100 Issued on March 20, 1984. Estimated Expiration Date:

December 28, 2001. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

2276882

3567821

Inventors

Assignee

A/S Orthana Kemisk Fabrik

Application

No. 06/336357 filed on 12/28/1981

US Classes:

424/537, Body fluid or exudate or transudate other than snake venom, feces, urine, or semen (e.g., lymph, saliva, honey, royal jelly, digestive juice, etc.)424/609, Thiocyanates424/610, Potassium or lithium containing424/613, Peroxide or compositions of or releasing gaseous oxygen or ozone424/616Hydrogen peroxide

Examiners

Primary: Rosen, Sam

Attorney, Agent or Firm

Cushman, Darby & Cushman

International Classes

A01N 59/00 (20060101)
A61K 8/64 (20060101)
A61K 9/00 (20060101)
A61L 2/00 (20060101)
C07K 14/47 (20060101)
A61L 2/18 (20060101)
A61K 8/30 (20060101)
A61Q 11/00 (20060101)
C07K 14/435 (20060101)
A61K 38/00 (20060101)

Foreign Application Priority Data

1980-04-25 DK

Abstract

Sterilized, preserved, stable mucine-containing solutions for use for application to sensitive human mucous membranes of the oral cavity, the nasal system, and the eye ephithel contain an oxidizing bactericide, in particular hydrogen peroxide, as preservative. Even at very small hydrogen peroxide concentrations, solutions remain bactericidal over prolonged periods such as 1-2 years. Mucine used is porcine gastric mucine or bovine salivary mucine or--to adjust the polar/non-polar properties--a mixture of both.The pronounced lubricating effect, combined with suitable viscosity, low surface tension and ability to coat and protect mucous membranes renders the solutions well suited as artificial salivas, ophthalmic solutions, and carriers for medicaments.