Stabilized estradiol cream composition
Patent 4436738 Issued on March 13, 1984. Estimated Expiration Date: 
March 15, 2002. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
March 15, 2002. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 2096744 Compositions containing alkali metal sulfate salts of conjugated estrogens and antioxidants as stabilizers Steroid formulation containing dipotassium EDTA Patent #: 4344940 InventorsAssigneeApplicationNo. 06/358068 filed on 03/15/1982US Classes:514/182, Oxygen single bonded to a ring carbon of the cyclopentanohydrophenanthrene ring system514/970CONTAINING DESIGNATED INGREDIENT TO STABILIZE AN ACTIVE INGREDIENTExaminersPrimary: Roberts, Elbert L.Attorney, Agent or FirmInternational ClassesA61K 47/00 (20060101)A61K 31/565 (20060101) AbstractLoss of potency of estradiol cream compositions found to be due to unexpected oxidation of estradiol. Improved cream composition comprises 1% or less 17ଲ-estradiol in the presence of stabilizing members selected from phenolic-type antioxidants, metal chelating agents, and suspending agents.Other References
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