Treatment of minimal brain dysfunction (MBD)

Patent 4435449 Issued on March 6, 1984. Estimated Expiration Date:

July 6, 2002. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

3819706

3885046

Inventor

Stern, Warren C.

Application

No. 06/395147 filed on 07/06/1982

US Classes:

427/330Vitreous coating

Examiners

Primary: Friedman, Stanley J.

Attorney, Agent or Firm

Brown; Donald

International Class

A61K 31/135 (20060101)

Abstract

A method of Treatment of Minimal Brain Dysfunction (MBD) also known as ATTENTION DEFICIT DISORDER in humans by the administration of the compound of the formula I ##STR1## or a pharmaceutically acceptable acid addition salt thereof in a non-toxic, effective therapeutic amount (calculated as base) to a human in need thereof.

Other References

Stern, Chem. Abst., vol. 92, 1980-34480
Canning et al., British J. of Pharmacology, (1979), 66, 104-105
Communications, J. Pharm. Pharmac. (1977), 29, pp. 767-770
Stern et al., Life Sciences, vol. 25, pp. 17-17-1724
Whiteman et al., J. Clin. Psychiatry, (1982), Failure of Bupropion to Affect Prolactin or Growth Hormone
Pharmacological and Biochemical Properties of Drug Substances, vol. 3, "Bupropion", R. A. Maxwell et al., Amer. Pharm. Ass. Academy of Pharm. Sciences-Publishe
Studies Concerning the Mechanism of the Antidepressant Activity of Bupropion, R. M. Ferris, J. Clin. Psychiatry (1982)
R. M. Ferris et al., Drug Development Research, 1:21-35, (1981)
Laakmann et al., Life Sciences, vol. 30, pp. 1725-1732
Butz et al., Impess: Jour. of Exp. Pharm. & Therapeutics (1982), The Relationship Between Bupropion Disposition and Dopamine Uptake in Rats and Mice
Neurochemical and Neuropharmacological Investigations into the Mechanisms of Action of Bupropion-HCl-A New Atypical Antidepressant Agent, Ferris et al., Typical and Atypical Antidepressants, Molecular Mechanisms, Raven Press, N.Y. (1982)