Crystalline benzothiazine dioxide salts
Patent 4434164 Issued on February 28, 1984. Estimated Expiration Date: 
April 13, 2002. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
April 13, 2002. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3591584 2-[(N-2-pyridylcarbamoyl)methyl]saccharin 4-Hydroxy-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxides and salts thereof Synthetic method and intermediate for piroxicam Patent #: 4289879 InventorApplicationNo. 06/367067 filed on 04/13/1982US Classes:514/226.5, One of the cyclos is a 1,2-thiazine (e.g.,1,2-benzothiazines, etc.)514/825, ARTHRITIS544/49Benzothiazines (including hydrogenated)ExaminersPrimary: Ford, John M.Attorney, Agent or FirmInternational ClassesC07D 417/00 (20060101)C07D 417/12 (20060101) AbstractThe water-soluble ethylenediamine, monoethanolamine and diethanolamine salts of N-(2-pyridyl)-2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide have been prepared. These novel crystalline salts are useful in therapy as non-steroidal anti-arthritic agents. Methods for preparing these salts from the corresponding acidic starting material and the appropriate amine base are provided.Other References
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