Piperid-4-yl ureas and thio ureas used as anti-depressant agents
Patent 4426387 Issued on January 17, 1984. Estimated Expiration Date: 
April 7, 2002. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
April 7, 2002. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.InventorsAssigneeApplicationNo. 06/366266 filed on 04/07/1982US Classes:514/329, Nitrogen attached directly to the piperidine ring by nonionic bonding514/352, Nitrogen attached directly to the six-membered hetero ring by nonionic bonding544/233, Polycyclo ring system having a 1,2-diazine ring as one of the cyclos544/237, Phthalazines (including hydrogenated)544/238, 1,2-diazines which contain an additional hetero ring546/112, Bicyclo ring system having the six-membered hetero ring as one of the cyclos546/123, Chalcogen and -C(=X)-, wherein X is chalcogen, bonded directly to ring carbons of the bicyclo ring system (e.g., 4-oxo-naphthyridine -3-carboxylic acid, etc.)546/124, Tropanes (including nor and dehydro forms)546/143, Nitrogen, other than as nitro or nitroso, attached directly to the isoquinoline ring system by nonionic bonding546/145, Acyclic nitrogen double or triple bonded to carbon which is attached directly or indirectly to the isoquinoline ring system by nonionic bonding546/146, Having -C(=X)-, wherein X is chalcogen, attached directly or indirectly to the isoquinoline ring system by nonionic bonding546/147, The -C(=X)- is part of a -C(=X)X- group, wherein the X's are the same or diverse chalcogens546/148, Unsaturated hetero ring attached indirectly to the isoquinoline ring system by nonionic bonding546/153, Chalcogen attached directly to the six-membered hetero ring by nonionic bonding546/159, Nitrogen, other than as nitro or nitroso, attached directly to the six membered hetero ring by nonionic bonding546/162, Nitrogen attached indirectly to the six-membered hetero ring through the directly attached nitrogen by nonionic bonding546/168, Having -C(=X)-, wherein X is chalcogen, bonded directly to the quinoline ring system546/169, Acyclic nitrogen bonded directly to the -C(=X)- group546/170, The -C(=X)- is part of a -C(=X)X- group, wherein the X's are the same or diverse chalcogens546/171, Nitrogen, other than as nitro or nitroso, attached directly to the carbocyclic ring of the quinoline ring system by nonionic bonding546/174, Having -C(=X)-, wherein X is chalcogen, attached indirectly to the quinoline ring system by nonionic bonding546/183, Chalcogen bonded directly to ring carbon of the bicyclo ring system546/193, Pyridine ring or partially hydrogenated pyridine ring546/194, Carbocyclic ring containing546/196, Hetero ring in the polycyclo ring system546/197, Plural ring hetero atoms in the polycyclo ring system546/200, Ring nitrogen in the polycyclo ring system546/201, Bicyclo ring system which is indole (including hydrogenated)546/202, Ring sulfur in the polycyclo ring system546/203, The polycyclo ring system is tricyclo-carbocyclic546/204, Chalcogen bonded directly to the tricyclo-carbocyclic ring system546/205, The polycyclo ring system is bicyclo-carbocyclic546/206, Chalcogen bonded directly to the bicyclo-carbocyclic ring system546/212, The additional hetero ring consists of one sulfur and four carbons546/214, The additional hetero ring consists of one oxygen and four carbons546/224, Acyclic nitrogen bonded directly to a -C(=X)- group, wherein X is chalcogen546/256, Additional hetero ring containing546/261, Chalcogen bonded directly to ring carbon of pyridine or partially hydrogenated pyridine ring546/262, Having -C(=X)-, wherein X is chalcogen, bonded directly to pyridine or partially hydrogenated pyridine ring546/263, The -C(=X)- is part of a -C(=X)X- group, wherein the X's are the same or diverse chalcogens546/264, Acyclic nitrogen attached directly or indirectly to pyridine or partially hydrogenated pyridine ring by nonionic bonding546/280.4, The additional hetero ring is five-membered546/281.1, Polycyclo ring system having the additional hetero ring as one of the cyclos546/281.4, Nitrigen attached directly to the six-membered hetero ring or to the additional hetero ring by nonionic bonding546/282.4, Plural ring oxygens in the additional hetero ring546/283.4, The additional hetero ring is five-membered546/284.1, Polycyclo ring system having the additional hetero ring as one of the cyclos546/284.4, Chalcogen attached directly to the additional hetero ring by nonionic bonding546/284.7, Nitrogen or -C(=X)-, wherein X is chalcogen, attached directly to the additional hetero ring by nonionic bonding546/285, Polycyclo-carbocyclic ring system having at least three cyclos546/305, Sulfur and acyclic nitrogen bonded directly to the same carbon546/306Plural acyclic nitrogens bonded directly to the same carbon or single bonded directly to each otherExaminersPrimary: Fan, Jane T.Attorney, Agent or FirmInternational ClassesC07D 211/00 (20060101)C07D 213/00 (20060101) C07D 211/72 (20060101) C07D 211/58 (20060101) C07D 213/75 (20060101) Foreign Application Priority Data1980-03-01 GBAbstractThe invention concerns compounds of formula ##STR1## and acid addition and quaternary ammonium salts thereof, wherein the dotted line represents an optional bond, Ar represents a ring system of formula ##STR2## in which Q is O,S,--CR7 =CR8 --, --N=CR8 -- and --N=N--; R4, R5 and R6, and R7 and R8 when present, each represent hydrogen or defined substituents and additionally either R4 and R5 when adjacent or R6 and R8 when adjacent, together with the carbon atoms to which they are attached also represent a fused five or six membered carbocyclic or heterocyclic ring optionally carrying one or more defined substituents; R is an optionally substituted aryl or heteroaryl radical or a cycloalkyl radical containing 5 to 7 carbon atoms; R1, R2, R3 and R9 are each hydrogen or a lower alkyl group; n is 0 or 1; X is =O, =S or =NH; Y is --O-- or a direct bond and Z is --CO-- or --CH2 -- with the proviso that when Ar is unsubstituted phenyl and R9 is hydrogen then Y is --O--. The compounds of formula I exhibit psychotropic activity and are useful as antidepressants. Processes for preparing the compounds and pharmaceutical compositions containing them are disclosed.Other References
Field of SearchAcyclic nitrogen bonded directly to a -C(=X)- group, wherein X is chalcogenThe polycyclo ring system is bicyclo-carbocyclic Chalcogen bonded directly to the bicyclo-carbocyclic ring system Sulfur and acyclic nitrogen bonded directly to the same carbon Plural acyclic nitrogens bonded directly to the same carbon or single bonded directly to each other |
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