U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Antiestrogenic and antiandrugenic benzothiophenes

Patent 4418068 Issued on November 29, 1983. Estimated Expiration Date: Icon_subject December 16, 2001. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3920707

Substituted benzofurans and benzothiophenes
Patent #: 3947470
Issued on: 03/30/1976
Inventor: Brenner ,   et al.

Certain 4-(3-azacycloalkoxy or azacycloalkylmethoxy)benzoylbenzofurans or benzothiophenes
Patent #: 3983245
Issued on: 09/28/1976
Inventor: Ladd ,   et al.

Substituted benzofurans and benzothiophenes
Patent #: 4001426
Issued on: 01/04/1977
Inventor: Brenner ,   et al.

Antifertility compounds
Patent #: 4075227
Issued on: 02/21/1978
Inventor: Jones ,   et al.

2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
Patent #: 4133814
Issued on: 01/09/1979
Inventor: Jones ,   et al.

Antifertility compounds Patent #: 4230862
Issued on: 10/28/1980
Inventor: Suarez ,   et al.

Inventor

Assignee

Application

No. 06/331042 filed on 12/16/1981

US Classes:

514/337, The additional hetero ring is one of the cyclos in a polycyclo ring system546/202, Ring sulfur in the polycyclo ring system546/237, The chalcogen, X, is in a -C(=X)- group549/51Chalcogen attached directly to the bicyclo ring system by nonionic bonding

Examiners

Primary: Schwartz, Richard A.

Attorney, Agent or Firm

International Classes

C07D 333/56 (20060101)
C07D 333/00 (20060101)

Abstract

6-Hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-piperidinoethoxy)benzoyl]benzo[b]thio phene, its ethers and esters, and the physiologically acceptable acid addition salts thereof, are valuable antiestrogens and antiendrogens.

Other References

  • Nicholson, R., et al., Europ. J. Cancer, 11, 571-579 (1975)
  • Ricciardi, I., et al., Ob. and Gyn., 54 (1), 80-84 (1979)
  • Jacquemier, J., et al., Cancer, 49 (12), 2534-2536 (1982)
  • Coombs, L. et al., Preven. Med., 8, 40-52 (1979)
  • Stoliar, B., et al., J. Urology, 111, 803-807 (1974)
  • Sogani, P., et al., J. Urology, 122, 640-643 (1979)
  • Caine, M., et al., J. Urology, 114, 564-568 (1975)
  • Geller, J., et al., Geriatrics, 63-71 (1977)
  • Ward, H., Br. Med. J., 1, 13-14 (1973)
  • Jordan, V., et al., J. Endocr., 68, 305-311 (1976)
  • Black, L., in Hormone Antagonists (Agarwal, Ed.), W. DeGruyter, New York, 1982, pp. 129-145
  • Claeys, N. et al., Chimie Therapeutique, 377-384 (1972)
  • Black, L., et al., Life Sciences 26, 1453-1458 (1980)
  • Lednicer, D., et al., J. Med. Chem. 10, 78-83 (1967)
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