Platinum-diamine complexes, a method for the preparation of a medicine using such a platinum-diamine complex for the treatment of malignant tumor in mice
Patent 4410544 Issued on October 18, 1983. Estimated Expiration Date: 
July 27, 2001. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
July 27, 2001. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3892790 3904663 Malonato platinum anti-tumor compounds Patent #: 4140707 InventorsAssigneeApplicationNo. 06/287531 filed on 07/27/1981US Classes:514/492, Heavy metal containing DOAI556/137, Nitrogen bonded directly to the metal556/40, Plural -C(=X)- groups, wherein X is chalcogen, bonded directly to the same non-benzenoid carbons, or the enolate thereof. (e.g., beta-diketone chelates, acetylacetonates, etc.)987/11Devoid of any platinum atom directly bonded to carbon (15/00N7B)ExaminersPrimary: Sneed, Helen M. S.Attorney, Agent or FirmInternational ClassC07F 15/00 (20060101)Foreign Application Priority Data1978-07-06 NLAbstractThis invention relates to novel platinum-diamine complexes having the formula: ##STR1## wherein R1 and R2 independently of each other may be selected from the group consisting of hydrogen, an alkyl group having 1-20 carbon atoms, a cycloalkyl group having from 3-7 carbon atoms in the ring, an aralkyl group, and an aryl group having 1-20 carbon atoms, whereas R1 and R2 together may form a cycloalkyl group having 3-7 carbon atoms in the ring and having the formula: ##STR2## wherein N is 2 to 7 and wherein R3 and R4 independently of each other are selected from the group consisting of hydrogen, an alkyl group having 1-20 carbon atoms, an aryl group or an aralkyl group having 1-20 carbon atoms in the alkyl group and X is an anionic group, providing that when X is either chlorine or malonate, R1, R2, R3 and R4 are not each H; when X is chlorine and R1 and R2 are each H, R3 and R4 are not each methyl; when X is chlorine and R1 and R2 are each methyl, R3 and R4 are not each H, and when X is chlorine R1 is hydrogen and R2 is methyl and R3 and R4 are not each hydrogen.Other References
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