U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Vitamin D glycosides and a method of use

Patent 4410515 Issued on October 18, 1983. Estimated Expiration Date: Icon_subject April 1, 2001. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Fluorovitamin D compounds and processes for their preparation Patent #: 4188345
Issued on: 02/12/1980
Inventor: DeLuca ,   et al.

Inventors

Assignee

Application

No. 06/249922 filed on 04/01/1981

US Classes:

514/35, Oxygen of the saccharide radical bonded directly to a cyclohexyl ring536/17.2, Nitrogen containing536/18.1, Polycyclo ring system (e.g., hellebrin, etc.)536/4.1, O- or S- Glycosides536/53, Oxygen double bonded and nitrogen bonded directly to the same carbon536/55.2, Glucosamine containing568/665, Polycyclo ring system568/817, Polycyclo ring system568/819Bicyclo ring system

Examiners

Primary: Brown, Johnnie R.

Attorney, Agent or Firm

International Classes

C07H 15/00 (20060101)
C07H 15/18 (20060101)
C07H 15/207 (20060101)

Abstract

A synthetic compound which is biologically active in maintaining calcium and phosphorous metabolism in animals, of the formula I ##STR1## wherein the double bond between positions C-22 and C-23 is single or double; R2 is hydrogen, CH3 or CH2 CH3 ; X is selected from the group consisting of hydrogen and --OR1, where R1 is hydrogen or a straight or branched chain glycosidic residue containing 1-20 glycosidic units per residue; with the proviso that at least one of the R1 is a glycosidic residue.

Other References

  • Haussler et al., Life Sciences, vol. 18, pp. 1049-1056, (1976)
  • Wassermann et al., Science, vol. 194: 853-855, (1976)
  • Napoli et al., Journal of Biological Chemistry 252: 2580-2583, (1977)
  • Wasserman, Science 183: 1092-1094, (1974)
  • LeVan et al., Biochemistry 20: 222-226, (Jan. 6, 1981)
  • Nagubandi et al., Journal of Clinical Investigation, vol. 66: 1274-1280, (Dec. 1980)
  • Hughes et al., Nature, 268: 347-349, (1977)
  • Peterlik et al., FEBS Ltrs. 56: 16-19, (1975)
  • Humphreys, Nature New Biology 246: 155-157, (1973)
  • Peterlik et al., Biochemical and Biophysical Research Communications 70: 797-804, (1976)
  • Holick et al., Biochemistry 10: 2799-2804, (1971)
  • Uribe et al., Biochemical and Biophysical Research Communications 58: 257-262, (1974)
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