U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Novel sulfonamide derivatives

Patent 4401663 Issued on August 30, 1983. Estimated Expiration Date: Icon_subject March 23, 2002. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3268582

Method for analgesia using 3-hydroxyacetanilide
Patent #: 4238508
Issued on: 12/09/1980
Inventor: Nelson

Method of producing analgesia Patent #: 4313958
Issued on: 02/02/1982
Inventor: LaHann

Inventors

Assignee

Application

No. 06/360953 filed on 03/23/1982

US Classes:

514/605, Q is acyclic and benzene ring in a substituent E514/604, Q is monocyclic564/84, Substituent Q contains benzene ring564/89, Hydroxy, bonded directly to carbon, or ether in substituent Q (H of -OH may be replaced by a substituted or unsubstituted ammonium ion or a Group IA or IIA light metal)564/92, Benzene ring in a substituent E564/95, Substituent Q is acyclic564/99, Benzene ring in a substituent E8/161Living animal

Examiners

Primary: Moyer, Donald B.
Assistant: Pepper, Frederick W.

Attorney, Agent or Firm

International Class

A61K 31/18 (20060101)

Abstract

A compound, or pharmaceutically acceptable salt thereof, having the formula: ##STR1## wherein X is ##STR2## wherein R is C3 -C12 alkyl or aralkyl, branched or unbranched, unsubstituted aryl, haloaryl, or C3 -C22 alkenyl, branched or unbranched; wherein R1 is H, OH or OCH3, and wherein R2 is OH or H, at least one of R1 and R2 being OH or OCH3. These sulfonamides have analgesic and anti-irritant activity when administered to humans and lower animals.

Other References

  • Challis et al., "Some Amines and Amides Derived from Vanillin," J. Chem. Soc., (1947), pp. 613-618
  • Kiernan, "A Study of Chemically Induced Acute Inflammation in the Skin of the Rat", Quart. J. Exp. Physiol., vol. 62, (1977), pp. 151-161
  • Jansco et al., "Direct Evidence for Neurogenic Inflammation and its Prevention by Denervation and by Pretreatment with Capsaicin," Br. J. Pharm. Chemother., vol. 31, (1967), pp. 138-151
  • Arvier et al., "Modification by Capsaicin and Compound 40/80 of Dye Leakage Induced by Irritants in the Rat," Br. J. Pharm., vol. 59, (1977), pp. 61-68
  • Yaksh et al., "Intrathecal Capsaicin Depletes Substance P in the Rat Spinal Cord and Produces Prolonged Thermal Analgesia," Science, vol. 260, (1979), pp. 481-483
  • Virus et al., "Pharmacologic Actions of Capsaicin: Apparent Involvement of Substance P and Serotonin," Life Sciences, vol. 24, (1979), pp. 1273-1281
  • Jones et al., "The Relation Between Chemical Constitution and Pungency in Acid Amides," J. Chem. Soc., vol. 27 (1925), pp. 2588-2598
  • Newman, "Natural and Synthetic Pepper-Flavored Substances," Chem. Prod., (Mar. 1954), pp. 102-106
  • Szolesanyi et al., "Sensory Effects of Capsaicin Congeners," Arzneim.-Forsch., vol. 25, (1975), pp. 1871-1881
  • Szolesanyi et al., "Sensory Effects of Capsaicin Congeners," Arzneim.-Forsch., vol. 26 (1976), pp. 33-37
  • Hegyes et al., "Synthesis of Homovanillic Acid Derivatives of Capsaicin-Like Effect," Acta. Phys. Chem., vol. 20, (1974), pp. 115-120
  • Michalska et al., "Synthesis and Local Anesthetic Properties of N-substituted 3,4-Dimethoxyphenethylamine Derivatives," Diss. Pharm. Pharmacol., vol. 24, (1972), pp. 17-25, (Chem. Abs. 77:19271a)
  • T. Szeki, "Contributions Towards Understanding the Relation Between the Chemical Constitution and the Sharp Taste of Acylamines," Arch. Pharm., vol. 268 (1930), pp. 151-157
PatentsPlus Images
Enhanced PDF formats
loading...
PatentsPlus: add to cart
PatentsPlus: add to cartSearch-enhanced full patent PDF image
$9.95more info
 
Sign InRegister
Username  
Password   
forgot password?