Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
Patent 4396542 Issued on August 2, 1983. Estimated Expiration Date: 
September 3, 2001. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
September 3, 2001. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesDihydrocyclosporin C Organic compounds Organic compounds Organic compounds Cyclosporin derivatives, their production and pharmaceutical compositions containing them Patent #: 4288431 InventorAssigneeApplicationNo. 06/299103 filed on 09/03/1981US Classes:530/321, Containing only normal peptide links in the ring, i.e., homodetic cyclic peptides930/20, Containing modified or unusual amino acid (See note 1 and note 2)930/21, Containing D-amino acid930/270Cyclic peptide or cyclic protein (See note 8)ExaminersPrimary: Phillips, Delbert R.Attorney, Agent or FirmInternational ClassesC07K 7/64 (20060101)C07K 7/00 (20060101) AbstractA method for the total synthesis of cyclosporins, in particular Cyclosporin A, cyclosporins produced in accordance with the method of the invention and novel intermediates, in particular novel [1S, 2R, 3R]- and [1R, 2S, 3S]-1-nitrilo-1-carbonyl-3-methyl-2-oxy-heptanes and -hept-5-enes, employed in the method of the invention.Other References
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