U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Systems for the controlled release of macromolecules

Patent 4391797 Issued on July 5, 1983. Estimated Expiration Date: Icon_subject August 10, 2001. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3854480

3880991

3903880

Copolymers
Patent #: 3957740
Issued on: 05/18/1976
Inventor: Blank ,   et al.

Vaginal drug dispensing device
Patent #: 4016251
Issued on: 04/05/1977
Inventor: Higuchi ,   et al.

Ocular therapeutic system manufactured from copolymer
Patent #: 4052505
Issued on: 10/04/1977
Inventor: Higuchi ,   et al.

Ocular therapeutic system with selected membranes for administering ophthalmic drug
Patent #: 4057619
Issued on: 11/08/1977
Inventor: Higuchi ,   et al.

Drug-delivery device comprising certain polymeric materials for controlled release of drug
Patent #: 4069307
Issued on: 01/17/1978
Inventor: Higuchi ,   et al.

Systems for the controlled release of macromolecules Patent #: 4164560
Issued on: 08/14/1979
Inventor: Folkman ,   et al.

Inventors

Assignee

Application

No. 06/291769 filed on 08/10/1981

US Classes:

424/425, Diffusion barrier is matrix424/427, Ocular424/430, Vaginal, urethral, uterine424/486, Synthetic polymer424/85.1LYMPHOKINE

Examiners

Primary: Rose, Shep K.

International Classes

A61K 9/00 (20060101)
A61K 9/16 (20060101)
A61K 9/20 (20060101)

Abstract

Delivery systems manufactured in the form of polymeric compositions for the controlled delivery of macromolecules to environments of use are disclosed. The systems are characterized as two-phase compositions comprising a phase formed of an insoluble polymeric matrix having limited water sorptivity containing in admixture therein an interpenetrating phase formed of a particulate hydrophilic water swellable, biologically active macromolecular material.

Other References

  • Chem. Abstracts 85, #42991j (1976) of Japan, Kokai 76 32785, Mar. 19, 1976, Kuraray-Immobilized Enzymes Entrapped in Ethylene-Vinylacetate-Vinyl Alcohol Copolymers
  • Chem. Abstracts 86, #13233d, #13234e, #13237h, #91290j, #67536y, #67983s, #116803u, (1977)
  • Chem. Abstracts 82, #1790r (1975) of Davis, B. K., Proc. Natl. Acad. Sci. USA, (1974) 71(81): 3120-3123, Diffusion in Polymer G&L Implants
  • Chem. Abstracts 77, #14570n (1972) of Davis, B. K., Experientia (1972) 28(3) 348, Control of Diabetes with Polyacrylamide Implants Cont'g Insulin
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