Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose
Patent 4389393 Issued on June 21, 1983. Estimated Expiration Date: 
March 26, 2002. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
March 26, 2002. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 2887440 3065143 3839319 3852421 3870790 4091205 Novel sustained release tablet formulations Sustained release therapeutic compositions Method and composition for the preparation of controlled long-acting pharmaceuticals Controlled release suppositories InventorsApplicationNo. 06/362104 filed on 03/26/1982US Classes:424/469, Discrete particles in supporting matrix424/480, Cellulose or derivative514/164, With organic oxygen containing compound514/180, 9-position substituted514/192, 1-thia-4-aza-bicyclo (3.2.0) heptane ring containing (including dehydrogenated) (e.g., penicillins, etc.)514/270, Barbituric acid or derivative (including thioanalogs)514/282, One of the five cyclos is five-membered and includes ring chalcogen (e.g., codeine, morphine, etc.)514/304, Tropanes (including nor or dehydro form)514/37, The nitrogen atoms are in N-C(=N)-N groups (e.g., streptomycin, etc.)514/781Cellulose or derivativeExaminersPrimary: Rose, Shep K.Attorney, Agent or FirmInternational ClassesA61K 9/20 (20060101)A61K 9/20 (20060101) AbstractA carrier base material combined with a therapeutically active medicament and shaped and compressed to a solid unit dosage form having a regular and prolonged release pattern upon administration, the carrier base material being one or more hydroxypropylmethylcelluloses or a mixture of one or more hydroxypropylmethylcelluloses and up to 30% by weight of the mixture of methylcellulose, sodium carboxymethylcellulose and/or other cellulose ether, and wherein at least one of the hydroxypropylmethylcelluloses has a methoxy content of 16-24 weight-%, a hydroxypropoxyl content of 4-32 weight-% and a number average molecular weight of at least 50,000 and wherein the carrier base material constitutes less than about one third of the weight of the solid unit dosage form. | |
