Pharmaceutical composition comprising modified polyriboinosinic-polyribocytidylic acid, for induction of interferon in primates
Patent 4388306 Issued on June 14, 1983. Estimated Expiration Date: 
February 8, 2002. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
February 8, 2002. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3679654 3725545 Nuclease-resistant hydrophilic complex of polyriboinosinic-polyribocytidylic acid Nucleic acid complexes Induction of interferon production by modified nucleic acid complexes Patent #: 4130641 InventorsAssigneeApplicationNo. 06/346673 filed on 02/08/1982US Classes:514/12, 25 or more peptide repeating units in known peptide chain structure514/889, INTERFERON INDUCER536/23.52, Interferon536/25.5, Homopolymers having repeating sequences of four or more identical nucleotide units930/290Polyamino acid or polypeptide with an uninterrupted series of peptide repeating unitsExaminersPrimary: Hazel, BlondelAttorney, Agent or FirmInternational ClassesA61K 31/74 (20060101)A61K 31/785 (20060101) C07H 21/00 (20060101) AbstractA complex of polyriboinosinic-polyribocytidylic acid (poly I:C) with poly-L-lysine hydrobromide ([lysine.HBr]n) having a defined molecular weight is prepared which is about 5-15 times as resistant to hydrolysis by pancreatic ribonuclease as the parent poly I:C. A pharmaceutical solution, containing a relatively high concentration of the complex, prepared as described, induces significant antiviral levels of serum interferon in monkeys under conditions in which poly I:C itself induces little or no interferon. An important feature of this invention is that the product is a soluble material requiring no special solubilizing agent, thereby facilitating the preparation of solutions having the desired concentration. The product will hereinafter be designated as poly I:C/poly-L-lysine.Other References
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