Novel cyclosporins

Patent 4384996 Issued on May 24, 1983. Estimated Expiration Date:

January 6, 2002. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

Dihydrocyclosporin C
Patent #: 4108985
Issued on: 08/22/1978
Inventor: Ruegger , et al.

Organic compounds
Patent #: 4117118
Issued on: 09/26/1978
Inventor: Harri , et al.

Organic compounds
Patent #: 4210581
Issued on: 07/01/1980
Inventor: Ruegger , et al.

Organic compounds
Patent #: 4220641
Issued on: 09/02/1980
Inventor: Traber , et al.

Cyclosporin derivatives, their production and pharmaceutical compositions containing them
Patent #: 4288431
Issued on: 09/08/1981
Inventor: Traber , et al.

Process for producing cyclosporin derivatives Patent #: 4289851
Issued on: 09/15/1981
Inventor: Traber , et al.

Inventors

Assignee

Sandoz Ltd.

Application

No. 06/337485 filed on 01/06/1982

US Classes:

530/321, Containing only normal peptide links in the ring, i.e., homodetic cyclic peptides930/20, Containing modified or unusual amino acid (See note 1 and note 2)930/21, Containing D-amino acid930/270Cyclic peptide or cyclic protein (See note 8)

Examiners

Primary: Phillips, Delbert R.
Assistant: Moezie, F. T.

Attorney, Agent or Firm

International Classes

C07K 7/64 (20060101)
C07K 7/00 (20060101)
A61K 38/00 (20060101)

Foreign Application Priority Data

1981-01-09 GB

Abstract

Novel cyclosporins having an -Allylgly- residue in the 2-position and/or a -(D)-Ser- residue in the 8-position and process for their production. The novel cyclosporins are useful as pharmaceuticals, e.g. as immunosuppressive and anti-inflammatory agents.