Monoclonal antibody to human helper T cells and methods of preparing same

Patent 4381295 Issued on April 26, 1983. Estimated Expiration Date:

April 26, 2000. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

Method of producing antibodies Patent #: 4196265
Issued on: 04/01/1980
Inventor: Koprowski , et al.

Inventors

Assignee

Ortho Pharmaceutical Corporation

Application

No. 06/033639 filed on 04/26/1979

US Classes:

530/388.75, Binds T-lymphocytic cell or component or product thereof (e.g., T cell, thymocyte, T-lineage bone marrow cell, T-lymphoblastoid cell, T-lineage acute lymphoblastic leukemia cell, T-lymphocytic cell-surface antigen, etc.)435/70.21, Producing monoclonal antibody435/966, INVOLVING AN ENZYME SYSTEM WITH HIGH TURNOVER RATE OR COMPLEMENT MAGNIFIED ASSAY (E.G., MULTI-ENZYME SYSTEMS, ETC.)436/548, Monoclonal antibody530/388.73, Binds lymphocytic or lymphocytic-like cell or component or product thereof (e.g., B cell, B-lineage bone marrow cell, null cell, natural killer cell, B-lymphoblastoid cell, B-lineage acute lymphoblastic leukemia cell, B-lymphocytic cell-surface antigen, etc.)530/808MATERIALS AND PRODUCTS RELATED TO GENETIC ENGINEERING OR HYBRID OR FUSED CELL TECHNOLOGY, E.G., HYBRIDOMA, MONOCLONAL PRODUCTS, ETC.

Examiners

Primary: Fagelson, Anna P.

Attorney, Agent or Firm

Dellenbaugh; Geoffrey G.

International Classes

C07K 16/30 (20060101)
C07K 16/18 (20060101)
C07K 16/28 (20060101)
A61K 38/00 (20060101)

Abstract

Hybrid cell line for production of monoclonal antibody to an antigen found on all normal human helper T cells. The hybrid is formed by fusing splenocytes from immunized CAF1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.

Other References

Kennett, SSIE Data Bank Abstract of Grant, 5/77-4/79, Ab. No. ICA 189303
Herzenberg et al., SSIE Data Bank, Abstract of Grant, 9/77-7/79, Ab. No. ICA468120
Melchers (Ed) Lymph. Hybridoms, 2nd. Workshop on Functional Properties of Tumors of T & B Lymph., Springer Verlag, Berlin, N.Y., 1978, pp. IX-XVIII
Yelton et al., Supra, pp. 1-7
Trucco et al., Supra, pp. 66-69
Levy et al., Supra, pp. 164-169
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Ruddle et al., Supra, pp. 203-211
Taniguchi et al., Supra, pp. 212-216
Osborne et al., Supra, pp. 217-220
Saravia et al., Supra, pp. 224-231
Fox, C & E News, Jan. 1, 1979, pp. 15-17
White et al., J. Exp. Med., vol. 148, Sep. 1, 1978, pp. 664-673
Herzenberg et al., from Wier (Ed.) Handbook of Exptl. Immunol., Blackwell, London, 3rd Ed., 1978, pp. 25.1-25.7