U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Lipid membrane drug delivery

Patent 4377567 Issued on March 22, 1983. Estimated Expiration Date: Icon_subject March 22, 2000. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Method for incorporating substances into protein microspheres
Patent #: 3937668
Issued on: 02/10/1976
Inventor: Zolle

Moisturizing units and moisturizing compositions containing the same Patent #: 3957971
Issued on: 05/18/1976
Inventor: Oleniacz

Inventor

Assignee

Application

No. 06/075310 filed on 09/13/1979

US Classes:

424/1.21, Molecular bilayer structure (e.g., vesicle, liposome)424/450, Liposomes424/85.4, Interferon427/213.3, Solid encapsulation process utilizing an emulsion or dispersion to form a solid-walled microcapsule (includes liposome)514/4, With an additional active ingredient514/78Lecithins

Examiners

Primary: Lovering, Richard D.

Attorney, Agent or Firm

International Classes

A61K 9/127 (20060101)
A61K 38/21 (20060101)
A61K 38/28 (20060101)
A61K 51/12 (20060101)

Abstract

Lipid Membrane Structures comprising Digalactosyl Diglyceride target the liver of humans and lower animals and are used to carry drugs to that organ, preferentially. Digalactosyl Diglyceride LMS containing insulin provide an effective means for treating diabetes mellitus. Digalactosyl Diglyceride LMS containing interferon are used to treat viral hepatitis.

Other References

  • Endocrinology 90, 12 (1972)-Canfield, Kay and West
  • Immunochemistry, 11, 475-481 (1974)
  • Lunny and Ashwell, Proc. Natl. Acad, Sci. USA, 73 341-343 (1976)
  • Mauk and Gamble, Proc. Natl. Acad. Sci. USA, 76, 356-369 (1979)
  • J. Lab. Clin. Med. 83 (4), 640-647 (1974)
  • FEBS Letters 62, 1, 60-63 (1976), Patel, et al
  • Proceedings of the Society for Experimental Biol. and Medicine 146, 1173-1176 (1974)
  • Biochimica et Biophysica Acta 311, 513-544 (1974)
  • Gebicki, et al., Chem. Phys. Lipids 16 (2), 142-160 (1976)
  • New England Journal of Medicine, 9/23/76, pp. 704-710 and 9/30/76, pp. 765-770
  • Journal of Lipid Research 9, 310-318 (1968)
  • Laboratory Investigation 34, No. 3, 276, et seq. (1976)
  • Proccedings of the National Academy of Sciences 71, No. 9, 3487-3491 (1974)
  • Life Sciences 17, 715-724
  • Chem. Pharm. Bull. 23 (10) 2218-2222 (1975)
  • Science News, vol. 114, No. 4, (7/22/78)
  • Gregoriadis, Biochemical Society Transactions, vol. 3 (1975), p. 613
  • Gregoriadis et al.: "Drug-Carrier Potential of Liposomes in Cancer Chemotherapy", The Lancet, Jun. 29, 1974, pp. 1313-1316
  • Shipley et al.: "The Phase Behavior of Monogalactosyl, Digalactosyl, and Sulphoquinovosyl Diglycerides", Biochimica et Biophysica Acta", 311 (1973), 531-544
  • Gregoriadis: "The Carrier Potential of Liposomes in Biology and Medicine", New England Journal of Medicine, Sep. 23, 1976, pp. 704-710
  • Roerdink et al.: Biochimica et Biophysica Acta, 677 (1981), pp. 79-89
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