Adenosine antagonists in the treatment and diagnosis of A-V node conduction disturbances
Patent 4364922 Issued on December 21, 1982. Estimated Expiration Date: October 14, 2000. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
424/9.1, IN VIVO DIAGNOSIS OR IN VIVO TESTING514/263.34Chalcogen bonded directly to the 2-and 6- positions of the purine ring system (e.g., theophylline, etc.)
A method of relieving atrioventricular conduction block by administering to a human or animal an effective amount of an adenosine antagonist that competitively inhibits adenosine or that reduces the level of adenosine present in myocardial tissue and associated fluids. A method of diagnosing atrioventricular conduction block caused by ischemia of the heart by measuring the time delay between atrial and ventricular excitation before and after the administration of an adenosine antagonist. Specific antagonists disclosed include methylxanthines.
Other References
Afonso, J. Physiol., vol. 241, 1974, pp. 299-308
Berne, American Journal of Physiology, vol. 204, pp. 317-322 (1963)
Rubio et al., Journal of Molecular and Cellular Cardiology, vol. 6, pp. 561-566 (1974)
Bunag et al., Circulation Research, vol. XV, pp. 83-88 (1964)
Katori et al., Circulation Research, vol. XIX, pp. 420-425 (1966)
Rubio et al., American Journal of Physiology, vol. 216, pp. 56-62 (1969)
Rubio et al., Circulation Research, vol. XXV, pp. 407-415 (1969)
Curnish et al., Proceedings of the Society for Experimental Biology and Medicine, vol. 141, pp. 593-598 (1972)
Wiedmeier et al., American Journal of Physiology, vol. 223, pp. 51-54 (1972)
Berne et al., "Challenges to the Adenosine Hypothesis for the Regulation of Coronary Blood Flow," in Current Topics in Coronary Research, Bloor and Olsson, editors, Plenem Publishing Corp., N.Y., pp. 3-10 (1973)
Rubio et al., American Journal of Physiology, vol. 225, pp. 938-953 (1973)
Thomas et al., Journal of Molecular and Cellular Cardiology, vol. 7, pp. 115-123 (1975)
Mustafa et al., American Journal of Physiology, vol. 228, pp. 1474-1478 (1975)
Foley et al., Journal of Molecular and Cellular Cardiology, vol. 10, pp. 293-300 (1978)
Foley et al., American Journal of Physiology, vol. 236, pp. H833-H838 (1979)
Watkinson et al., American Journal of Physiology, vol. 236, pp. H13-H21 (1979)
Jacob et al., American Journal of Physiology, vol. 198, pp. 322-326 (1960)
Jacob et al., Proceedings of the Society for Experimental Biology and Medicine, vol. 107, pp. unknown (1961)
Miller et al., Circulation Research, vol. 45, pp. 708-718 (1979)
Berne et al., Circulation Research, vol. 35, pp. 262-271 (1974)
Rubio et al., American Journal of Physiology, vol. 228, pp. 1896-1902 (1975)
Winn et al., Circulation Research, vol. 45, pp. 486-492 (1979)
Berne et al., "Mechanism of Adenosine Incorporation into Brain," source unavailable
Winn et al., "Brain Adenosine Production During the Initial 60 Seconds of Bicuculline Seizures in Rats," source unavailable
Winn et al., "Changes in Adenosine During Sustained Hypoxia," source unavailable
Dobson et al., Circulation Research, vol. XXIV, pp. 375-384 (1971)
Bockman, et al., Pflugers Arch, vol. 355, pp. 229-241 (1975)
Bockman et al., American Journal of Physiology, vol. 230, pp. 1531-1537 (1976)
Schraeder et al., Journal of Molecular and Cellular Cardiology, vol. 7, pp. 427-433 (1975)
Imai et al., Circulation Research, vol. XV, pp. 443-450 (1964)
Belardinelli et al., Pflugers Arch., vol. 380, pp. 19-27 (1979)
Berne et al., "Effect of Adenosine on Contraction of Vascular Smooth Muscle," in Ionoic Actions on Vascular Smooth Muscle, Betz, editor, Springer-Verlag, Berlin, pp. 137-140 (1976)
Herlihy, et al., American Journal of Physiology, vol. 230, pp. 1239-1243 (1976)
Harder et al., Circulation Research, vol. 44, pp. 176-172 (1979)
Schraeder et al., American Journal of Physiology, vol. 223, pp. 159-166 (1972)
Berne et al., "Response of Large and Small Coronary Arteries to Adenosine, Nitroglycerine, Cardiac Glycosides, and Calcium Antagonists," source unavailable
Berne, Physiological Reviews, vol. 44, pp. 1-29 (1964)
Berne et al., American Journal of Cardiology, vol. 24, pp. 776-781 (1969)
Berne et al., Circulation, Supp. IV to vols. XXXIX and XL, pp. IV-240-IV-251 (1969)
Berne et al., Advances in Cardiology, vol. 5, pp. 56-66 (1970)
Berne et al., Circulation Research, Supp. I to vols. XXVII and XXIX, pp. I-115-I-119 (1971)
Berne et al., Circulation Research, Supp. III to vols. 34 and 35, pp. III-109-III-120 (1974)
Miller et al., Circulation Research, pp. 390-397 (1978)
Berne et al., American Journal of Physiology, vol. 229, pp. 1625-1631 (1975)
Jageneau et al., Naunyn-Schmiedebergs Arch. Pharmak., vol. 256, pp. 16-23 (1969)
Stafford, British Journal of Pharmacology and Chemotherapy, vol. 28, pp. 218-226 (1966)
Afonso et al., Circulation Research, vol. XXII, pp. 43-48 (1968)
Bittar et al., Pharmacological Research Communications, vol. 2, pp. 231-242 (1970)
Nott, British Journal of Pharmacology, vol. 39, pp. 287-295 (1970)
Afonso, Circulation Research, vol. XXVI, pp. 743-752
Kubler et al., Journal of Molecular and Cellular Cardiology, vol. 1, pp. 23-38 (1970)
Miura et al., "Potentiation of Reactive Hyperemia in the Coronary and Femoral Circulation by the Selective Use of 2,6-Bis(Diethanolamino)-4,8-dipiperidinopyrimidol[5,4-d]pyrimidine," source unavailable
Olsson et al., Circulation Research, vol. 39, pp. 93-98 (1976)
Olsson et al., Federation Proceedings, vol. 37, pp. 418 (1978)
Olsson et al., Life Sciences, vol. 21, pp. 1343-1350 (1977)
Schrader et al., Pflugers Arch, vol. 369, pp. 251-257 (1977)
Drury et al., Journal of Physiology (London), vol. 68, pp. 214-237 (1929)
Cook et al., Circulation Research, vol. VI, pp. 735-739 (1958)
Buckley et al., Circulation Research, vol. IX, pp. 242-249 (1961)
Richman et al., American Journal of Physiology, vol. 207, pp. 1139-1142 (1964)
Olsson et al., American Journal of Physiology, vol. 208, pp. 231-236 (1965)
Olsson, Circulation Research, vol. XXVI, pp. 301-306 (1970)
Olsson et al., Circulation Research, vol. XXXI, pp. 767-778 (1972)
Schrader et al., Pflugers Arch, vol. 369, pp. 1-6 (1977)
Schrader et al., Pflugers Arch, vol. 372, pp. 29-35. (1977)
Olsson et al., Circulation Research, vol. 42, pp. 358-362 (1978)
Schnaar et al., American Journal of Physiology, vol. 223, pp. 223-228 (1972)
de Gubareff et al., Journal of Pharmacology and Experimental Therapeutics, vol. 148, pp. 202-214 (1965)
Bittar et al., American Journal of Physiology, vol. 220, pp. 812-815 (1971)
Afonso et al., Journal of Physiology (London), vol. 221, pp. 589-599 (1972)
Bunger et al., Pflugers Arch, vol. 358, pp. 213-224 (1975)
Merrill et al., Circulation Research, vol. 42, pp. 225-229 (1978)
Giles et al., Cardiovascular Research, vol. 11, pp. 113-121 (1977)
Afonso et al., Basic Research in Cardiology, vol. 70, pp. 390-400 (1975)
Mitenko et al., New England Journal of Medicine, vol. 289, pp. 600-603 (1973)
Adgey et al., Lancet, pp. 1097-1101 (1968)
Tans et al., "A-V Nodal Block In Acute Myocardial Infarction," source not available