U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Adenosine antagonists in the treatment and diagnosis of A-V node conduction disturbances

Patent 4364922 Issued on December 21, 1982. Estimated Expiration Date: Icon_subject October 14, 2000. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3317533

3493573

3928609

Mepyramine theophylline acetate
Patent #: 3962243
Issued on: 06/08/1976
Inventor: Roldan ,   et al.

Pharmaceutical compositions containing adenine derivatives
Patent #: 3989833
Issued on: 11/02/1976
Inventor: Jonas ,   et al.

Process for the production of stabilized pure theophylline in neutral, aqueous solution
Patent #: 4117132
Issued on: 09/26/1978
Inventor: Seebach

Basic substituted xanthine derivatives
Patent #: 4144340
Issued on: 03/13/1979
Inventor: Offermanns ,   et al.

Dihydroxyphenylethylaminoalkyl theophyllines Patent #: 4153696
Issued on: 05/08/1979
Inventor: Kleemann ,   et al.

Inventors

Assignee

Application

No. 06/196652 filed on 10/14/1980

US Classes:

424/9.1, IN VIVO DIAGNOSIS OR IN VIVO TESTING514/263.34Chalcogen bonded directly to the 2-and 6- positions of the purine ring system (e.g., theophylline, etc.)

Examiners

Primary: Fagelson, Anna P.

Attorney, Agent or Firm

International Classes

A61K 31/52 (20060101)
A61K 31/519 (20060101)
A61K 31/46 (20060101)

Abstract

A method of relieving atrioventricular conduction block by administering to a human or animal an effective amount of an adenosine antagonist that competitively inhibits adenosine or that reduces the level of adenosine present in myocardial tissue and associated fluids. A method of diagnosing atrioventricular conduction block caused by ischemia of the heart by measuring the time delay between atrial and ventricular excitation before and after the administration of an adenosine antagonist. Specific antagonists disclosed include methylxanthines.

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