Transdermal carrier materials
Patent 4362737 Issued on December 7, 1982. Estimated Expiration Date: 
April 13, 2001. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
April 13, 2001. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesImidazolinium compounds Patent #: 4267350 InventorsApplicationNo. 06/253876 filed on 04/13/1981US Classes:514/120, C=O other than as ketone or aldehyde, attached directly or indirectly to phosphorus514/161, With heterocyclic compound514/171, With additional active ingredient514/356, C=O in a C(=O)O group (e.g., nicotinic acid, etc.)514/399, Chalcogen or nitrogen bonded indirectly to the imidazole ring by nonionic bonding514/56, Heparin or derivative514/94, Diazoles (including hydrogenated)548/112, Phosphorus attached indirectly to the five-membered hetero ring by nonionic bonding548/347.1, One double bond between ring members of the diazole ring (i.e., imidazoline)548/349.1, Chalcogen attached indirectly to the diazole ring by acyclic nonionic bonding548/350.1, Chalcogen attached indirectly to the diazole ring by acyclic nonionic bonding (e.g., hydroxyalkyl glyoxalidine, etc.)548/352.1, The chalcogen, X, is in a -C(=X)X- group, wherein X`s are the same or diverse chalcogens562/561, Plural nitrogens562/565, Polycarboxylic987/224P is pentavalent and contains the structure P-(O-C) or P-(O-Z) where Z indicates an atom other than H (9/09; 9/09A1)ExaminersPrimary: Schwartz, Richard A.International ClassesC07D 233/18 (20060101)C07D 233/00 (20060101) C07F 9/6506 (20060101) C07F 9/00 (20060101) C07F 9/09 (20060101) AbstractAmphoteric dissociating complexes which have a cationic group having the structure ##STR1## wherein: R1 is an aliphatic alkyl group having 6 to 22 carbons,R2 is a member of the group consisting of --R4 --(CH2 CH2)--COOH, --R4 --(CH=CH)COOH and --OPO3 H2, wherein R4 is --NH--, --NH--CO--, or --O--CO--, andR3 is hydrogen, --CH2 --COOH or --CH2 --CH2 --COOH; and an anionic group which is either a carboxylate having the formula or a phosphate having the formula wherein:n is 8 to 22 and x is 1 to 10; and z is 1 when the anionic radical is a carboxylate and z is 2 when the anionic radical is a phosphate are disclosed.The compositions are effective carriers for active pharmaceutical or cosmetic ingredients. The active ingredients may be ionically complexed with the cationic or anionic group of the amphoteric complex or may be covalently bonded to one of the groups of the complex. Alternatively, the active substances may be transported in the carriers as micellar inclusions. |
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