Process for producing a multi-layered slow release composite
Patent 4359483 Issued on November 16, 1982. Estimated Expiration Date: 
February 10, 2001. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
February 10, 2001. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesControlled release tablet Coating ensuring a controlled release of active ingredients of biologically active compositions, particularly pharmaceutical compositions and a process for preparation of biologically active compositions ensuring controlled release of active ingredients Biochemical avidin-biotin multiple-layer system Method for preparing preparations having controlled release of an active component Patent #: 4289795 InventorsAssigneeApplicationNo. 06/233135 filed on 02/10/1981US Classes:427/2.21, Retarded or controlled-release layer produced (e.g., enteric)424/485, Natural gums, resin or latex424/486, Synthetic polymer424/487, Acrylic acid and derivatives424/488, Polysaccharides (e.g., cellulose, etc.)427/214, Applying superposed diverse coatings or coating a coated base427/222, Resin base427/398.1, Cooling427/496, High energy electromagnetic radiation or high energy particles utilized (e.g., gamma rays, X-rays, atomic particles, i.e., alpha rays, beta rays, electrons, etc.)427/508, Low energy electromagnetic radiation utilized (e.g., UV, visible, IR, microwave, radio wave, actinic, laser, etc.)428/407Including synthetic resin or polymerExaminersPrimary: Lusignan, Michael R.Attorney, Agent or FirmInternational ClassesA61K 9/20 (20060101)A61K 9/70 (20060101) A61K 9/24 (20060101) Foreign Application Priority Data1980-02-27 JPAbstractA process is herein disclosed for producing a multi-layered slow release composite comprising: a first step wherein one or more physiologically active substances is mixed with one member selected from the group consisting of one or more supercooling polymerizable vinyl monomers, one or more natural or synthetic polymeric substances and a mixture thereof, and the mixture is given a predetermined shape and subjected to a physical treatment to form a slow release composite; a second step wherein a predetermined thickness of coating of one member selected from the group consisting of one or more supercooling polymerizable vinyl monomers, one or more natural or synthetic polymeric substances and a mixture thereof is formed on the surface of said slow release composite, which then is subjected to a physical treatment so that a layer wherein no physiologically active substance is encapsulated is formed on the surface of said slow release composite; a third step wherein a predetermined thickness of coating of a mixture of one or more physiologically active substances with one member selected from the group consisting of one or more supercooling polymerizable vinyl monomers, one or more natural or synthetic polymeric substances and a mixture thereof is formed on the surface of the slow release composite having the layer provided in the second step wherein no physiologically active substance is encapsulated, said composite then is subjected to a physical treatment to form a layer wherein the physiologically active substance is encapsulated. | |
