Carrier base material for prolonged release therapeutic compositions

Patent 4357469 Issued on November 2, 1982. Estimated Expiration Date:

June 29, 2001. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

3590117

3594467

3870790

Sustained release therapeutic compositions Patent #: 4226849
Issued on: 10/07/1980
Inventor: Schor

Inventor

Schor, Joseph M.

Application

No. 06/278568 filed on 06/29/1981

US Classes:

536/91, Hydroxyalkyl containing106/162.82, The carbohydrate is diverse cellulose ether or salt thereof (i.e., mixture of two or more cellulose ethers or salts of diverse etherifying radicals or mixture of two or more cellulose mixed ethers or salts of different diverse etherifying radical groups)106/181.1, With organic -C(=O)O- group containing compound except wax (e.g., fatty acid, dicarboxylic acid, etc.)106/184.1, Plural -C(=O)O- groups attached directly or indirectly to each other by nonionic bonding106/198.1, With elemental metal or alloy or metal compound536/85, Subsequent treatment process536/87Liquid interaction properties changed (e.g., solubility, absorbability, etc.)

Examiners

Primary: Griffin, Ronald W.

Attorney, Agent or Firm

Jacobs & Jacobs

International Class

A61K 9/20 (20060101)

Abstract

A carrier base material adapted to be combined with a therapeutically active medicament and shaped and compressed to form a sustained release therapeutic composition having a long-lasting, slow and regular incremental release of the medicament upon administration, the carrier base material being hydroxypropylmethylcellulose or a mixture of hydroxypropylmethylcellulose and either up to 30% ethylcellulose or 30% sodium carboxymethylcellulose or both, and wherein the carrier base material has been subjected to hydrolysis and oxidation successively or concurrently until the carbonyl content ranges from 0.2-3.0 grams/100 grams, the carboxyl content ranges from 0.60-2.60 grams/100 grams and the moisture content is in the range of 0.5-3.9%.