U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Time-release chemical delivery system

Patent 4356166 Issued on October 26, 1982. Estimated Expiration Date: Icon_subject October 26, 1999. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3639516

Polyanhydroglucose biodegradable polymers and process of preparation
Patent #: 3950282
Issued on: 04/13/1976
Inventor: Gilbert ,   et al.

Normally-solid, bioabsorbable, hydrolyzable, polymeric reaction product Patent #: 4122129
Issued on: 10/24/1978
Inventor: Casey ,   et al.

Inventors

Application

No. 05/967605 filed on 12/08/1978

US Classes:

525/54.1, Containing chemically combined protein or biologically active polypeptide424/426, Errodable, resorbable, or dissolving424/47, Topical live body grooming or adorning aid (e.g., hair spray, antiperspirant, etc.)514/2, Peptide containing (e.g., protein, peptones, fibrinogen, etc.) DOAI514/955, Biodegradable type514/964, SUSTAINED OR DIFFERENTIAL RELEASE TYPE525/359.4, Organic halogen-containing compound contains a (C=O)O group or an aromatic group525/380, Amine contains a hydroxyl group525/445, Mixed with ethylenically unsaturated reactant or polymer therefrom525/455, Mixed with ethylenically unsaturated reactant or polymer therefrom530/336, Of side chain or sulfur containing group530/345Chemical aftertreatment, e.g., acylation, methylation, etc.

Examiners

Primary: Roberts, Elbert L.

Attorney, Agent or Firm

International Class

A61K 47/48 (20060101)

Abstract

A time-release chemical delivery system in which a bioactive compound is attached to a polymeric biodegradable carrier by a hydrolyzable bond is disclosed. The bioactive compound can either be bound directly to the polymer or be attached to the polymer via a spacer group. The composition of the system is particularly effective for delivering medication systemically to a host animal over a prolonged period of time after being surgically implanted or injected subcutaneously. Biodegradable condensation polymers having reactive pendant groups, for example, poly-L-(glutamic acid), or derivatized poly-L-(glutamic acid) are effective as polymeric carriers.

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