Patent References 3639516 Polyanhydroglucose biodegradable polymers and process of preparation Normally-solid, bioabsorbable, hydrolyzable, polymeric reaction product Patent #: 4122129 InventorsApplicationNo. 05/967605 filed on 12/08/1978US Classes:525/54.1, Containing chemically combined protein or biologically active polypeptide424/426, Errodable, resorbable, or dissolving424/47, Topical live body grooming or adorning aid (e.g., hair spray, antiperspirant, etc.)514/2, Peptide containing (e.g., protein, peptones, fibrinogen, etc.) DOAI514/955, Biodegradable type514/964, SUSTAINED OR DIFFERENTIAL RELEASE TYPE525/359.4, Organic halogen-containing compound contains a (C=O)O group or an aromatic group525/380, Amine contains a hydroxyl group525/445, Mixed with ethylenically unsaturated reactant or polymer therefrom525/455, Mixed with ethylenically unsaturated reactant or polymer therefrom530/336, Of side chain or sulfur containing group530/345Chemical aftertreatment, e.g., acylation, methylation, etc.ExaminersPrimary: Roberts, Elbert L.Attorney, Agent or FirmInternational ClassA61K 47/48 (20060101)AbstractA time-release chemical delivery system in which a bioactive compound is attached to a polymeric biodegradable carrier by a hydrolyzable bond is disclosed. The bioactive compound can either be bound directly to the polymer or be attached to the polymer via a spacer group. The composition of the system is particularly effective for delivering medication systemically to a host animal over a prolonged period of time after being surgically implanted or injected subcutaneously. Biodegradable condensation polymers having reactive pendant groups, for example, poly-L-(glutamic acid), or derivatized poly-L-(glutamic acid) are effective as polymeric carriers. |
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