2-(Piperazinyl)-4-pyrimidinamines
Patent 4351832 Issued on September 28, 1982. Estimated Expiration Date: 
March 20, 2001. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
March 20, 2001. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3511836 Process for hypotensive 4-amino-2-(piperazin-1-yl) quinazoline derivatives Oxazole, isoxazole, thiazole and isothiazole amides N-(2-benzimidazolyl)-piperazines Alkoxy-substituted-6-chloro-quinazoline-2,4-diones Patent #: 4287341 InventorAssigneeApplicationNo. 06/245798 filed on 03/20/1981US Classes:514/171, With additional active ingredient514/218, Hetero ring is seven-membered consisting of two nitrogens and five carbon atoms514/223.5, With additional active ingredient514/249, 1,4-diazine as one of the cyclos514/252.17, The polycyclo ring system is quinazoline (including hydrogenated)514/252.18, Additional six-membered hetero ring consisting of five ring carbons and one ring nitrogen attached directly or indirectly to the 1,3-diazine by nonionic bonding514/252.19, Five-membered nitrogen hetero ring attached directly or indirectly to the 1,3-diazine ring by nonionic bonding540/575, The nitrogens are in the 1,4-positions of the hetero ring544/284, Additional nitrogen containing unsaturated hetero ring (e.g., thiazole, etc.)544/291, Nitrogen bonded directly at 2- and 4-positions544/295Plural diazine ringsExaminersPrimary: Coughlan, Paul M. Jr.Attorney, Agent or FirmInternational ClassesA61K 45/00 (20060101)A61K 45/06 (20060101) C07D 239/00 (20060101) C07D 239/95 (20060101) C07D 239/48 (20060101) C07D 498/04 (20060101) C07D 498/00 (20060101) AbstractHerein is disclosed 2-(1-piperazinyl)-4-pyrimidinamine derivatives, acid addition salts thereof, processes for their preparation, methods of using the derivatives and pharmaceutical compositions of the derivatives. The derivatives are distinguished most readily by having novel substituents at position 4 of the piperazinyl radical, the substituents being selected from the group consisting of 2-thiazoylyl, oxazolo(4,5-b)pyridin-2-yl and optionally substituted 1-(lower alkyl)-1H-benzimidazol-2-yl. The derivatives are useful for treating hypertension in a mammal.Other References
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