Sustained release pharmaceutical composition of solid medical material
Patent 4343789 Issued on August 10, 1982. Estimated Expiration Date: July 2, 2000. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
514/356, C=O in a C(=O)O group (e.g., nicotinic acid, etc.)424/497, Containing solid synthetic polymers426/33, Isolated triglyceride other than milk derived426/80, Having flow compeller means, e.g., compressor, etc.426/81Tapered gathered closure
Sustained release pharmaceutical composition of a solid medical material which contains an amorphous solid medical material, polyethylene oxide, and at least one basic substance selected from the group consisting of hydroxypropylmethyl cellulose, hydroxypropyl cellulose, methyl cellulose, polyvinyl pyrrolidone, carboxyvinyl polymer, hydroxypropylmethyl cellulose phthalate, cellulose acetate phthalate, methyl meta-acrylate meta-acrylic acid copolymer, polyvinylacetal diethylaminoacetate, dimethylaminoethyl meta-acrylate meta-acrylic acid copolymer, 2-methyl-5-vinylpyridinemethyl acrylate meta-acrylic acid copolymer, citric acid, urea, succinic acid and amino acid, and may further contain one basic substance selected from the group consisting of a surface active agent, polyethylene glycol, propylene glycol, glycerin, a glycerin fatty acid ester and a vegetable oil (first embodiment): and in the case where the solid medical material is nicardipine, the composition may consist only of the amorphous nicardipine or a salt thereof without the above compound (second embodiment).
Chem. Abstracts 93 #220596j (1980) of Bayer A/G, Jpn. Kokai Tokkyo Koho 80 64,570, May 15, 1980
Chem. Abstracts 93 #150124c (1980) of Bayer A/G, Ger. Offen. 2,847,237, May 14, 1980
Chem. Abstracts 83 #209407w (1975) of Ger. Offen. 2,400,819 Jul. 17, 1975, Finely divided preparation of difficultly soluble pharmaceuticals, Kramer R. R. Amor et al
Chem. Abstracts 87 #28914w (1977) of Eckert, T. et al. Arch. Pharm. (Weinhelm, Ger.) 1977, 310(2), 116-118, Polymorphic modifications of Nifedipine from supercooled melts
Chem. Abstracts 90 #109987m (1979) of Ger. Offen. 2,822,882 Dec. 21, 1978, Kawata et al., Nifedipine solid preparations
Chem. Abstracts 91 #112451h (1979) of Jpn. Kokai Tokkyo Koho 79 46,837, Apr. 13, 1979 Kanebo, Ltd., Nifedipine-containing vasodilating compositions with good absorption