Pyrrolidinylalkylcarboxylic acid amide derivatives, their preparation and pharmaceutical compositions containing them
Patent 4341790 Issued on July 27, 1982. Estimated Expiration Date: 
June 3, 2000. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
June 3, 2000. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 2778834 Pyrrolidine derivatives 4-Hydroxy pyrrolidin-2-onyl-amides Preparation of pyrrolidine and pyrrolidin-2-one derivatives Patent #: 4173569 InventorsApplicationNo. 06/155952 filed on 06/03/1980US Classes:514/424, Chalcogen bonded directly to the five-membered hetero ring by nonionic bonding546/278.4, Chalcogen attached directly to the five-membered hetero ring by nonionic bonding546/278.7, Plural chalcogens attached directly to the five-membered hetero ring by nonionic bonding548/523, Ring nitrogens of the two nitrogen containing hetero rings are bonded directly to the same atom or chain, which chain may include a ring548/544, And chalcogen bonded directly to a ring carbon of the five membered hetero ring which is not adjacent to the ring nitrogen (e.g., 2,4 pyrrolidinediones, etc.)548/550Nitrogen attached directly or indirectly to the five-membered hetero ring by acyclic nonionic bondingExaminersPrimary: Rollins, Alton D.Attorney, Agent or FirmInternational ClassesC07D 207/27 (20060101)C07D 207/00 (20060101) C07D 207/273 (20060101) Foreign Application Priority Data1979-06-13 DEAbstract2-Oxo-1-pyrrolidinylalkylcarboxylic acid amides of formula I ##STR1## in which R represents a hydrogen atom or hydroxy group, R1 represents a hydrogen atom or a methyl group and R2 represents a substituted or unsubstituted pyridyl group or a substituted phenyl group, the substitution being by from 1 to 3 substituents, which may be the same or different selected from halogen atoms, trifluoromethyl, nitro and acetyl groups, straight or branched-chain alkyl groups having 1-4 carbon atoms, alkoxy groups having 1-4 carbon atoms, straight or branched-chain alkylmercapto groups having 1-7 carbon atoms, substituted alkylmercapto groups of the general formula II ##STR2## in which n represents 1 or 2, R3 is a hydrogen atom or a methyl group and R4 is a hydroxy group or an amino group of the general formula V ##STR3## in which R8 represents a hydrogen atom or methyl group and R9 represents a methyl group or substituted or unsubstituted benzyl group, or R8 and R9 together with the nitrogen atom shown in formula V, form a substituted pyrrolidine ring; sulphonyl groups of the general formula IIIin which R5 represents an --NH2 group or an alkyl group having 1-3 carbon atoms; and aminoethoxycarbonyl groups of the general formula IV ##STR4## in which each of R6 and R7, which may be the same or different, represents a hydrogen atom or methyl or ethyl group; and the pharmaceutically tolerable acid addition salts of compounds of formula I having a basic nitrogen atom are useful in treating cerebral circulatory disturbances, cerebro-atrophic crises and cerebral ageing processes.Other References
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