Enkaphalin derivatives
Patent 4341698 Issued on July 27, 1982. Estimated Expiration Date: 
March 14, 2000. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
March 14, 2000. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesLong-lasting agonists of enkephalin Patent #: 4254107 InventorsAssigneeApplicationNo. 06/130431 filed on 03/14/1980US Classes:544/384, Chalcogen bonded directly to piperazine ring carbon530/302Endorphin and Enkephalin; related peptidesExaminersPrimary: Phillips, Delbert R.Attorney, Agent or FirmInternational ClassesC07D 241/00 (20060101)C07D 241/08 (20060101) C07K 5/00 (20060101) C07K 5/078 (20060101) C07K 5/117 (20060101) A61K 38/00 (20060101) AbstractNovel analgesic and antipsychotic agents having the formula ##STR1## wherein Q is ##STR2## in which R1 is hydrogen, hydroxy or halogen and R4 is hydrogen or, R1 and R4 are both hydroxy; Z is hydrogen or straight chain lower alkyl having from 1 to 4 carbon atoms and X is methylene, carbonyl, hydroxymethylene, thio, sulfinyl or sulfonyl, or Z and X, taken together, are methylidenyl, with the proviso that when X is sulfonyl or sulfinyl, Z is other than hydrogen; R5 is hydrogen or halogen, and R2 is H, a straight or branched lower alkyl group having from 1 to 4 carbon atoms, the group ##STR3## or the group ##STR4## wherein R3 is hydroxy, amino, alkylamino or dialkylamino wherein the alkyl moiety is straight or branched and has from 1 to 4 carbon atoms, diastereomers, enantiomers and pharmaceutically acceptable salts thereof.Other References
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