U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Method of diagnosing periodontal disease through the detection of pyridine compounds

Patent 4334540 Issued on June 15, 1982. Estimated Expiration Date: Icon_subject June 15, 1999. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Method of predicting and detecting ovulation
Patent #: 3986494
Issued on: 10/19/1976
Inventor: Preti ,   et al.

Method of predicting and detecting ovulation
Patent #: 4010738
Issued on: 03/08/1977
Inventor: Preti ,   et al.

Method of predicting and determining ovulation by monitoring the concentration of volatile sulfur-containing compounds present in mouth air Patent #: 4119089
Issued on: 10/10/1978
Inventor: Preti ,   et al.

Inventors

Assignee

Application

No. 06/035018 filed on 05/01/1979

US Classes:

600/300, DIAGNOSTIC TESTING436/161, INCLUDING CHROMATOGRAPHY436/91, HETEROCYCLIC CARBON COMPOUND (I.E., O, S, N, SE, TE, AS ONLY RING HETERO ATOM)600/530, Halitosis detection600/532Qualitative or quantitative analysis of breath component

Examiners

Primary: Fagelson, Anna P.

Attorney, Agent or Firm

International Class

G01N 33/52 (20060101)

Abstract

A novel method of diagnosing periodontal disease is disclosed wherein telltale pyridine and alkyl-pyridine compounds which are detected in the oral cavity are indicative of periodontal disease. An alternate embodiment method is disclosed wherein increased concentrations of certain other compounds are detected to confirm the presence of periodontal disease.

Other References

  • Tonzetich, Arch. Oral Biol., vol. 9, 1964, pp. 39-45
  • Lindhe, J. Periodont. Res., vol. 2, 1967, pp. 194-198
  • Zelson et al., IADR Abstracts, 1978, J. Dent. Res., vol. 57, Jan. 1978, Ab. No. 679
  • Dreizen, Oral Surg., vol. 9, 1956, pp. 278-283
  • Main, Brit. J. Dermat., vol. 79, 1967, pp. 20-30
  • Teranishi, Analytical Chem., vol. 44, 1972, pp. 18-20
  • Chen, J. Lab. & Clin. Med., vol. 75, 1970, pp. 622-627, and 628-635
  • Charalambous (Ed), Analysis of Foods & Beverages, Acd. Press, N. Y., 1978, pp. 283-357
  • Kostelc et al., IADR Abstrats, 1979, J. Dent. Res., vol. 58, Jan. 1979, Ab. No. 325
  • Dolby (Ed), Oral Mucosa in Health & Dis., Blackwell Sci. Pub. Oxford, pp. 113-116
  • Afonsky, Saliva & Its Relation to Oral Health, U. of Ala. Press, 1961, pp. 97-104
  • Brunneman, Chem. Abs., vol. 89, 1978, Ab. No. 89:194115x
  • Golub, J. Periodont. Res., vol. 6, 1971, pp. 243-251
  • Loe, Acta Odont. Scand., vol. 21, 1963, pp. 533-549
  • Rizzo, Periodontics, vol. 5, No. 5, 1967, pp. 233-236
  • Lindhe, J. Perodont. Res., vol. 3, 1968, pp. 12-20
  • Miles, Brit. Dent. J., vol. 105, No. 7, 1958, pp. 235-248
  • McNamara, Oral Surg., vol. 34, Jul. 1972, pp. 41-48
  • Loe, J. of Periodont., vol. 36, 1965, pp. 37/209-45/217
  • Grant, WHM, Toxicology of the Eye, C. C. Thomas, Pub., 1962
  • Lorber, Am. Rev. Respiratory Dis., vol. 112, 1975, pp. 875-876
  • Berg, J. Dent. Res., vol. 26, 1947, pp. 67-71
  • Law, J. Dent. Res., vol. 22, 1943, pp. 373-379
  • Ramfjord, J. Periodont., vol. 30, 1959, pp. 51-59
  • Tonzetich, J. Int. Med. Res., vol. 6, 1978, pp. 245-254
  • Tonzetich, Archs. Oral Biol., vol. 16, 1971, pp. 587-597
  • Thompson, Analytical Chem., vol. 47, Jul. 1975, pp. 1313-1321
  • Tonzetich, J. Periodont., vol. 48, 1977, pp. 13-20
  • Rao, J. Dent. Res., vol. 57(A), 1978, p. 244, Ab. No. 680
  • Labows, J. of Chromat. Biomed. Applications, vol. 163, 179, pp. 294-299
  • Tonzetich, Int. Dent. J., vol. 28, 1978, pp. 309-319
  • Doty, R., "Procedure for Combining Menstrual Cycle Date", Journal of Clinical Endocrinology & Metabolism, vol. 48, No. 6, Jun. 1979, pp. 912-918
  • Watson, Analytical Chem., vol. 37, Jun. 1965, pp. 844-851
  • Moss, C. W. and S. B. Dees, "Cellular fatty acids and metabolic products of Pseudomonas species obtained from clinical specimens"; Journal of Clinical Microbiology 4: 492-502 (1976)
  • Wade, T. J. and R. J. Mandel, 1974, "New gas Chromatographic characterization procedure": preliminary studies on some Pseudomonas species Applied Microbiology 27: 303-311, Feb. 1974
  • Tonzetich, Oral Surg., vol. 42, 1976, pp. 172-181
  • Charles D. Cox and J. Parker, "Use of 2-aminoacetophenone production in identification of Pseudomonas aeruginosa", Journal of Clinical Microbiology, Apr. 1979, 9: 479-484
  • Hayward et al., "Development of specific tests for rapid detection of E. coli and species of Proteus in urine", Journal of Clinical Microbiology, Sep. 1977, 6: 195-201
  • Van den Dool, J. of Chromat., vol. 11, 1963, pp. 463-471
  • Miller et al., "Volatile Compounds Produced in Sterile Fish (Sebastes malanops) by Pseudomonas putrefaciens, Pseudomonas fluorescens, and an Achromobacter Species", Applied Microbiology, 26: 18-21, Jul. 1973
  • Lee et al., "High resolution gas chromatographic profiles of volatile organic compounds produced by microorganisms at refrigerated temperatures", Applied and Environmental Microbiology No. 1 37: 85-90, Jan. 1979
  • Tonzetich, Archs. Oral Biol., vol. 23, 1978, pp. 875-880
  • Brunn et al., "Epidemiology of Pseudomanas aeruginosa infections: determination by Pyocin typing", Journal of Microbiology, 3: 264-271 (1976)
  • Laraya-Cuasay et al., "Pseudomonas carrier rates of patients with cystic fibrosis and of members of their families", Journal of Pediatrics, 89: 23-26 (1980)
  • Tonzetich, Archs. Oral. Biol., vol. 14, 1969, pp. 815-827
  • Mitruka, "Gas chromatography application in microbiology and medicine", (1979), John Wiley & Sons, New York, Chapter 13, 352-374
  • Brooks et al., "Further studies on the differentiation of Clostridium sordelli from Clostridium bifermentans by gas chromatography", Canadian Journal of Microbiology 16: 1071-1078 (1970)
  • Holzer, J. of Chromat., vol. 142, 1977, pp. 755-764
  • "Analysis by gas chromatography of fatty acids found in whole cultural extracts of Neisseria species", Can. J. Microbiol. 17: 531-541 (1970)
  • Brooks et al., "Analysis by gas chromatography of hydroxy acids produced by several species of Neisseria", Canadian Journal of Microbiology 18: 157-168 (1972)
  • Golub, Oral Sci. Rev., vol. 8, pp. 49-61
  • Kostelc et al., "Salivary volatiles as indicators of periodontitis", J. Periodont. Res. 18: 185-192 (1980)
  • Matsumota et al., "Identification of volatile compounds in human urine", J. Chromatogr. 85: 31-34 (1973)
  • Rooth, The Lancet, II, 19 Nov. 1966, pp. 1102-1105
  • Zlatkis et al., "Concentration and analysis of volatile urinary metabolites", J. Chromatogr. Sci. 11: 299-302 (1973)
  • Reiner et al., "Botulism: A pyrolysis-gas-liquid chromatographic study", J. Chromatogr. Sci. 16: 623-629 (1978)
  • Russell, J. Dent. Res., vol. 35, 1956, pp. 350-359
  • Bohannon et al., "Quantitative methods for the gas chromatographic characterization of acidic fermentation by-products of anaerobic bacteria", J. of Chromatogr. Sci. 16: 28-35 (1978)
  • Larsson et al., "Analysis of Amines and other bacterial products by head-space gas chromatography", Acta Path. Microbiol. Scand. Section B 86: 207-213 (1978)
  • Simenhoff, N. E. J. Med., vol. 297, 1977, pp. 132-135
  • Hayward et al., "Methylmercaptan and DMDS production from methionine by Proteus Species Detected by Head-Space Gas-Liquid Chromatography", J. of Clin. Microbiol. 6: 187-194 (1977)
  • Labows et al., "Characteristic Gamma-Lactone odor production of the genus Pityrosporum", Appl. and Environ. Micro. 38: 412-415 (1979)
  • Sicher(ed) Orban's Oral Histology & Embryology, Mosby, St. Louis, 1972, pp. 269-271
  • Morgan, "The chemistry of some microbially-induced flavor defects in milk and dairy foods", Biotech. Bioeng. 18: 953-965 (1976)
  • Liebich et al., "Volatile substances in blood serum: profile analysis and quantitative determination", J. Chromatogr. 142: 505-516 (1977)
  • Holm-Pedersen, J. Periodont. Res., vol. 2, 1967, pp. 13-20
  • Withycombe et al., "Isolation and identification of volatile components from wild rice grain", J. of Agricultural Food Chemistry, vol. 6, pp. 816-821, (1978)
  • Budzikiewicz et al., "Mass spectrometry of organic compounds", p. 155, Holden-Day, Inc., San Francisco (1967)
  • Iusem, Oral Surg., vol. 3, 1950, pp. 1516-1520
  • Dwivedi et al., "Carbonyl production from lipolyzed milk fat by the continuous mycelial culture of Penicillium roqueforti", J. Food Science, 39: 83-137 (1974)
  • Burger et al., "Ketones from the pedal gland of the bontebok", Z. Naturforsch C: Bioscience, 316: (1-2): 21-28 (1976)
  • Hafez(ed), The Human Vagina, North-Holland Pub., N. Y., 1978, pp. 151-166
  • Albone et al., "Bacteria as a source of chemical signals in Mammals", reprinted pp. 35-43 in D. MullerSchwarze & M. M. Mozell, Editors, Chemicals Signals in Vertebrates, Plenum Press, N.Y. (1977)
  • Ikeshoji, "Bacterial production of the ovipositional attractants for mosquitos on fatty acid substrates", App. Ent. Zool. 10: 239-242, (1975)
  • Jellum, Analytical Chem., vol. 45, 1973, pp. 1099-1106
  • Labows et al., "Headspace Analysis of Volatile Metabolites of Pseudamonas aerugino and Related Species by Gas Chromatography-Mass Spectrometry", J. Clin. Microbiol., vol. 12, Oct. 1980, pp. 521-526
  • Gorbach, S. L., J. W. Mayhew, J. G. Bartlett, II. Thadepalli, and A. B. Onderdonk. Rapid Diagnosis of anaerobic infections by direct gas-liquid chromatography of clinical specimens, J. Clin. Invest. 57: 478-484, (1976)
  • Hutterer, Clin. Chem., vol. 17, 1971, pp. 789-794
  • Berg and Fosdick, J. Dental Res., vol. 25, pp. 73-81 (1946)
  • Tonzetich, Arch. Oral Biology, 4: 587-597, (1971)
  • Zlatkis, Chromatographia, vol. 6, 1973, pp. 67-70
  • Berg et al., J. Dental Res., vol. 26, pp. 67-71 (1947)
  • Jamison, J. 1960 Prevalence and Severity of Periodontal Disease on a Sample Population, Thesis, University of Michigan, School of Public Health, Ann Arbor
  • Dubowski, Clin. Chem., vol. 20, No. 8, 1974, pp. 966-972
  • Tonzetich, J. Oral Malodour: An Indicator of Health Status and Oral Cleanliness. Int. Dent. J., 28: 309-319 (1978)
  • Silness, Acta Odont. Scand., vol. 22, 1964, pp. 121-135
  • DePaola, Nutrition Today, vol. 12, 1977, pp. 6-11, 29-32
  • Hardie, The Normal Microbial Flora of Man, Acd. Press, N. Y., 1974, pp. 47-61
  • Spouge, The Dental Pract., vol. XIV, Apr. 1964, pp. 307-317
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