U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

TCA Composition and method for rapid onset antidepressant therapy

Patent 4310524 Issued on January 12, 1982. Estimated Expiration Date: Icon_subject April 11, 2000. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Inventors

Application

No. 06/139498 filed on 04/11/1980

US Classes:

514/217, Tricyclo ring system having the seven-membered hetero ring a one of the cyclos514/220, Tricyclo ring system having the seven-membered hetero ring as one of the cyclos514/252.17, The polycyclo ring system is quinazoline (including hydrogenated)514/280, Pentacyclo ring system having the six-membered hetero ring as one of the cyclos514/321, Plural hetero atoms in the polycyclo ring system514/401, 2-imidazolines514/646Benzene ring containing

Examiners

Primary: Friedman, Stanley J.

Attorney, Agent or Firm

International Class

A61K 31/55 (20060101)

Abstract

A method is provided for treating depression in a patient therefrom and requiring rapid symptomatic relief, which comprises administering to said patient concurrently (a) an effective antidepressant amount of a tricyclic antidepressant or a pharmaceutically effective acid addition salt thereof, and (b) an amount of an ଱-adrenergic receptor blocking agent effective to achieve rapid onset of the antidepressant action of (a), whereby the onset of said antidepressant action is achieved within from 1 to 7 days.A pharmaceutical composition is also provided which is especially adapted for use with the foregoing method.

Other References

  • Chemical Abst., vol. 66-72828m, (1967), Kellett
  • Chemical Abst., vol. 68-94371a, (1968), Martelli et al
  • Chemical Abst., vol. 74-86048j, (1971), Dixit et al
  • Holmberg et al., Psychopharm., 2, 93 (1961)
  • Svensson, Symp. Med. Hoechst., 13, 245 (1978)
  • McMillen et al., Fed. Proc., 38, 592 (1979)
  • Sellinger et al., Fed. Proc., 38, 592 (1979)
  • Pandey et al., Fed. Proc., 38, 592 (1979)
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