Abstract

There are described compounds of formula I, ##STR1## in which R1 is phenyl substituted by halogen, alkoxy, alkyl, carboxy-alkyl, --NR4 R5, carboxy or alkoxy carbonyl,R3 is hydrogen, alkyl, mono- or di-carboxy alkyl, halo, alkoxy, phenyl, halo-phenyl, hydroxy, phenoxy, thiol, thioalkoxy, thiophenoxy, --NR4 R5, cyano, --COOH, carboxyureido, --CF3, --COR6, hydroxyalkyl, aminoalkyl, or alkoxy substituted by NR4 R5,ring A is a benzene or a pyridine ring which optionally carries up to 4 substituents R3, which may be the same or different,R4 and R5, which may be the same or different, each represent hydrogen, phenyl, halophenyl or alkyl, the alkyl optionally being substituted by alkoxy or by a mono- or di-alkyl or unsubstituted amino group; or R4 and R5, together with the nitrogen atom to which they are attached, form a piperidine, morpholine or an optionally alkyl substituted piperazine ring, andR6 is hydrogen or alkyl,provided that (i) when R1 is phenyl substituted by chlorine or bromine, ring A is not a benzene ring substituted by chlorine or bromine, or (ii) when R1 is phenyl substituted by methoxy R3 is not phenyl, and pharmaceutically acceptable salts, esters and amides thereof.There are also described methods for making the compounds and pharmaceutical, e.g. anti-inflammatory, compositions containing the compounds.