Derivatives of doxorubicine, their preparation and use
Patent 4296105 Issued on October 20, 1981. Estimated Expiration Date: July 5, 1999. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
514/34, Oxygen of the saccharide radical bonded directly to a polycyclo ring system of four carbocyclic rings (e.g., daunomycin, etc.)536/6.4, Daunomycin or derivative549/417Plural chalcogens bonded directly to the hetero ring
New derivatives of doxorubicine of the formula ##STR1## wherein R represents a radical of the formula ##STR2## wherein R1 represents hydrogen, alkyl (possibly substituted with amino, alkylamino, dialkylamino, hydroxy, mercapto or methylthio), phenyl, benzyl (possibly substituted with one or more hydroxy) and R2 represents hydrogen or forms with R1 an alkylene radical, the salts thereof and pharmaceutical compositions containing said compounds.They are prepared according to methods known in peptidic chemistry by reacting a reactive form of an aminoacid of the formula ##STR3## with doxorubicine.