Transdermal medication system for isosorbide dinitrate
Patent 4293565 Issued on October 6, 1981. Estimated Expiration Date: 
October 9, 1999. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
October 9, 1999. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesTherapy of leg muscle cramps Patent #: 4112115 InventorsAssigneeApplicationNo. 06/082490 filed on 10/09/1979US Classes:514/470Chalcogen or nitrogen bonded directly to the hetero ringExaminersPrimary: Cacciapaglia, Frank Jr.International ClassesA61K 9/70 (20060101)A61K 47/00 (20060101) A61K 31/34 (20060101) Foreign Application Priority Data1979-06-13 DEAbstractA pharmaceutical preparation comprising:(a) isosorbide dinitrate as active ingredient(b) a solvent for isosorbide dinitrate(c) an ointment consistency agent(d) an emulsifying agent(e) water, and(f) possibly customary preservatives, antioxidants, buffers and/or odorants;where the weight ratio of water: consistency agent including emulsifying agent: solvent is 30 to 80: 3 to 35: 3 to 35, the amount of emulsifying agent is from 0% to 15% by weight and the amount of isosorbide dinitrate is from 2% to 20% by weight. The preparation has an ointment-like consistency and is administered topically to the skin, where it has a high adsorption rate and a long duration of response.Other References
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