Derivatives of A-30912A nucleus
Patent 4293483 Issued on October 6, 1981. Estimated Expiration Date: 
August 25, 2000. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
August 25, 2000. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3150059 Antibiotic aculeacins Antibiotic A-30912 and process for production thereof Antibiotic A-22082 and process for production thereof Process of preparing desacyl-pepsidine with bacillus pumilus Antibiotic S 31794/F-1 Patent #: 4173629 InventorAssigneeApplicationNo. 06/181030 filed on 08/25/1980US Classes:530/317, Cyclic peptides435/68.1, Enzymatic production of a protein or polypeptide (e.g., enzymatic hydrolysis, etc.)435/71.1Using a micro-organism to make a protein or polypeptideExaminersPrimary: Phillips, Delbert R.Attorney, Agent or FirmInternational ClassesC07K 7/56 (20060101)C07K 7/00 (20060101) A61K 38/00 (20060101) AbstractCompounds of the formula ##STR1## wherein R1 is an N-alkanoyl amino acyl group of the formula ##STR2## wherein: W is a divalent aminoacyl radical of the formula: ##STR3## wherein A is C1 -C10 alkylene or C5 -C6 cycloalkylene; ##STR4## wherein R3 is hydroxymethyl, hydroxyethyl, mercaptomethyl, mercaptoethyl, methylthioethyl, 2-thienyl, 3-indole-methyl, phenyl, benzyl, or substituted phenyl or substituted benzyl in which the benzene ring thereof is substituted with chloro, bromo, iodo, nitro, C1 -C3 alkyl, hydroxy, C1 -C3 alkylthio, carbamyl, or C1 -C3 alkylcarbamyl; ##STR5## wherein X is hydrogen, chloro, bromo, iodo, nitro, C1 -C3 alkyl, hydroxy, C1 -C3 alkoxy, mercapto, C1 -C3 alkylthio, carbamyl, or C1 -C3 alkylcarbamyl; ##STR6## wherein X1 is chloro, bromo, or iodo; ##STR7## wherein B is a divalent radical of the formula: --(CH2)n --, wherein n is an integer from 1 to 3; --CH=CH--; --CH=CH--CH2 --; ##STR8## and R2 is C1 -C17 alkyl or C2 -C17 alkenyl; have antifungal activity.Other References
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