Certain heterocyclic-methylthioalkyl guanidine derivatives
Patent 4282234 Issued on August 4, 1981. Estimated Expiration Date: 
May 14, 1999. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
May 14, 1999. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3868457 Pharmacologically active guanidine compounds Sulphoxides Certain thiazoles and oxazoles N-Oxy and N-amino guanidines Amidino compounds Process for preparing N-cyanoguanidines Pharmacologically active compounds Heterocyclic-methylthioethyl-dithiocarbamates and isothioureas Patent #: 4120966 InventorsAssigneeApplicationNo. 06/039090 filed on 05/14/1979US Classes:514/363, 1,3,4-thiadiazoles (including hydrogenated)514/365, 1,3-thiazoles (including hydrogenated)514/372, 1,2-thiazoles (including hydrogenated)514/378, 1,2-oxazoles (including hydrogenated)548/136, 1,3,4-thiadiazoles (including hydrogenated)548/138, Nitrogen attached directly to the thiadiazole ring by nonionic bonding548/142, Chalcogen bonded directly to the 2- and 5- positions of the thiadiazole ring548/182, Chalcogen bonded directly to ring carbon of the thiazole ring548/190, Nitrogen attached directly to the thiazole ring by nonionic bonding548/193, Chalcogen attached indirectly to the thiazole ring by nonionic bonding548/213, Chalcogen bonded directly to ring carbon of the thiazole ring548/214, Nitrogen or chalcogen attached indirectly to the thiazole ring by nonionic bonding548/240, 1,2-oxazoles (including hydrogenated)548/243, Chalcogen bonded directly to ring carbon of the oxazole ring548/245Nitrogen bonded directly to ring carbon of the oxazole ringExaminersPrimary: Rotman, Alan L.Attorney, Agent or FirmInternational ClassesC07D 233/54 (20060101)C07D 249/08 (20060101) C07D 249/00 (20060101) A61K 31/33 (20060101) C07D 261/14 (20060101) C07D 261/00 (20060101) C07D 275/00 (20060101) C07D 275/02 (20060101) C07D 277/48 (20060101) C07D 277/00 (20060101) C07D 233/00 (20060101) C07D 277/26 (20060101) C07D 285/00 (20060101) C07D 285/12 (20060101) Foreign Application Priority Data1974-03-12 GBAbstractThe compounds are N-(heterocyclomethylthioalkyl)derivatives of alkylguanidines, C-alkyl and C-aryl amidines and S-alkylisothioureas. The compounds may also have N'-lower alkyl or N'-(heterocyclomethylthioalkyl)substituents. Three compounds of the invention are S-methyl-N-[2-(5-methyl-4-imidazolylmethylthio)ethyl]isothiourea, N,N'-bis-[2-(5-methyl-4-imidazolymethylthio)ethyl]acetamidine, N,N'-bis-[2-(5-methyl-4-imidazolymethylthio)ethyl]N"-methylguanidine. The compounds of this invention are histamine H2 -antagonists.Other References
Field of SearchChalcogen bonded directly to ring carbon of the thiazole ringNitrogen attached directly to the thiazole ring by nonionic bonding Chalcogen attached indirectly to the thiazole ring by nonionic bonding 1,3,4-thiadiazoles (including hydrogenated) Nitrogen attached directly to the thiadiazole ring by nonionic bonding Chalcogen bonded directly to the 2- and 5- positions of the thiadiazole ring Chalcogen bonded directly to ring carbon of the thiazole ring 1,2-oxazoles (including hydrogenated) Chalcogen bonded directly to ring carbon of the oxazole ring |
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