Microporous-semipermeable laminated osmotic system
Patent 4256108 Issued on March 17, 1981. Estimated Expiration Date: 
May 21, 1999. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
May 21, 1999. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesNovel drug delivery device Osmotic releasing device having a plurality of release rate patterns Osmotic releasing system for administering ophthalmic drug to eye of animal Osmotic system having laminated wall comprising semipermeable lamina and microporous lamina Patent #: 4160452 InventorApplicationNo. 06/034275 filed on 05/21/1979US Classes:424/424, Membrane or diffusion barrier424/427, Ocular424/428, Bioerrodable, resorbable, or dissolving424/431, Tampon424/435, Mouth424/436, Anal, rectal (e.g., suppositories, etc.)424/437, Otic424/449, Transdermal or percutaneous424/473With porous, perforated, apertured, or sieved layer (e.g., dialyzing layer, microporous layer, etc.)ExaminersPrimary: Michell, Robert W.Assistant: Rosenbaum, C. Fred Attorney, Agent or FirmInternational ClassA61F 9/00 (20060101)AbstractAn osmotic therapeutic system for delivering a drug is disclosed. The system comprises a drug delivery module which module comprises a rate controlling laminated wall surrounding a reservoir and has a portal for delivering drug from the system. The laminated wall comprises a semipermeable lamina in laminar arrangement with a microporous lamina to provide a wall that is permeable to an external fluid, impermeable to drug and maintains its integrity during the delivery of drug. The reservoir contains a drug, or a mixture of drug and a solute which drug or solute is soluble in the fluid and exhibits an osmotic pressure gradient across the wall against the fluid. In operation, drug is released from the system by fluid being imbibed through the wall into the reservoir at a rate determined by the permeability of the wall and the osmotic pressure gradient across the wall thereby producing a solution of drug, or a solution of solute containing drug which solution is released through the portal at a controlled rate over a prolonged period of time. | |
