Homocysteine thiolactone perchlorate as a tumor promotor
Patent 4255443 Issued on March 10, 1981. Estimated Expiration Date: 
November 16, 1999. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
November 16, 1999. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References3068242 InventorApplicationNo. 06/094814 filed on 11/16/1979US Classes:514/445, Chalcogen bonded directly to ring carbon of the hetero ring549/63Nitrogen attached directly to the hetero ring by nonionic bondingExaminersPrimary: Siegel, AlanAttorney, Agent or FirmInternational ClassA61K 31/38 (20060101)AbstractHomocysteine thiolactone perchlorate is prepared from the corresponding homocysteine thiolactone hydrochloride and optimally about two equivalents of perchloric acid as reactants. A preferred solvent utilized is chloroform-methanol (4:1) solution and a preferred temperature range is 0°-85° C. with the lower limit dependent upon the particular solvent and the upper limit of about 186° C. dependent upon the melting point of the product crystals. The preferred perchloric acid reactant may be replaced with perchlorate salts such as AgClO4 or KClO4. The product perchlorate salt is soluble in organic solvents, whereas other known salts such as the hydrochloride are only water soluble. This property is thought to influence the growth effect of the perchlorate salt in animals, such as rabbits, and to influence the unique effect of the perchlorate salt on the growth of malignant tumors in animals, such as mice. |
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