Method of encapsulating biologically active materials in lipid vesicles
Patent 4241046 Issued on December 23, 1980. Estimated Expiration Date: 
November 30, 1998. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
November 30, 1998. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesMethod for incorporating substances into protein microspheres Process for the preparation of liposomes Patent #: 4089801 InventorsApplicationNo. 05/964815 filed on 11/30/1978US Classes:424/420, Waxes, fatty acids, etc. (e.g., liposome, etc.)424/450LiposomesExaminersPrimary: Phillips, Delbert R.Assistant: Hazel, Blondel Attorney, Agent or FirmInternational ClassesA01N 25/28 (20060101)A01N 25/26 (20060101) A61K 9/127 (20060101) AbstractThe disclosure is of a method for encapsulating biologically active materials in synthetic, oligolamellar lipid vesicles (liposomes). The method comprises providing a mixture of lipid in organic solvent and an aqueous mixture of the material for encapsulation, emulsifying the provided mixture, removing the organic solvent and suspending the resultant gel in water. The method of the invention is advantageous over prior art methods of encapsulating biologically active materials in that it provides a means for a relatively high capture efficiency of the material for encapsulation. The disclosure is also of intermediate compositions in the encapsulation method, the product vesicles, compositions including the product vesicles as an active ingredient and their use.Other References
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